Identifying Prognostic Markers in Sepsis
Official title: Identification de Marqueurs de Mauvais Pronostic Clinique du Sepsis Par Analyse épigénétique.
Run by Assistance Publique Hopitaux De Marseille · NCT06446947 · Data updated 2026-11-12
This study is trying to find new signs in the blood that can help predict which patients with severe sepsis might develop septic shock after major surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years to 75 Years |
| Sex | Men only |
| Enrollment | 25 (estimated) |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille, Bouches du Rhône) |
| Status | Recruiting |
| Started | March 20, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT06446947 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are male patients aged 45 to 75 who are undergoing major esophageal or digestive surgery and have post-operative gram-negative bacterial sepsis.
✕Probably not a fit
Patients outside the age range of 45 to 75, female patients, or those with non-carcinological surgeries will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify new prognostic markers for the progression of sepsis to septic shock by comparing epigenetic markers in patients who develop severe forms of sepsis against those who do not. The study involves blood sampling from male patients aged 45 to 75 who are undergoing major esophageal or digestive surgery and have post-operative gram-negative bacterial sepsis. By analyzing these markers, researchers hope to better understand the factors that influence the clinical outcomes of sepsis.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools for predicting the progression of sepsis, potentially enhancing patient management and outcomes.
How similar studies have gone: While this approach is focused on epigenetic markers in sepsis, similar studies have shown promise in identifying prognostic factors in other critical conditions, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male patients, * Patients between 45 and 75 years of age, * Patients undergoing major esophageal or digestive carcinological surgery, * Patients with post-operative gram-negative bacterial sepsis (proven or suspected in the context of organ failure). Exclusion Criteria: * patients under 45 and aged 76 and over, * female patients, * non-carcinological or minor surgery, * non-esophageal or non-digestive surgery, * Gram-positive bacterial or fungal infections in the absence of associated BGN, * patients with hematological cancer, * immunocompromised patients, * septic surgery (surgical site infection), * patients expressing opposition to data collection and analysis (clinical and/or biological) within the regulatory framework of the study, * patients under guardianship or curatorship, * patients not affiliated to a social security system or equivalent in France, * patients deprived of their liberty.
Where it's running
-
Service Anesthésie Réanimation - Hôpital Nord - Assistance Publique Hôpitaux de Marseille
Marseille, Bouches du Rhône, France Recruiting
Study contacts
- Study coordinator: Marc LEONE, MD PHD
- Email: marc.leone@ap-hm.fr
- Phone: 0491968655
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Personalized care approach for patients with suspected sepsis
This study is testing new ways to diagnose sepsis in about 1500 adults who show signs of it when they arrive at the emergency department, to help create more personalized treatment plans.
-
Non-invasive hemodynamic guidance for sepsis care on medical wards
This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.
-
Personalized Fluid Resuscitation in the Emergency Department
This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.
-
Discordance between capillary refill time and oxygen use in septic shock
This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.
-
Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock
This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.
-
Cortisol Levels and Mortality in Septic Shock ICU Patients
This study tests whether cortisol levels can predict death or recovery in adults with sepsis or septic shock in the ICU.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.