Antibiotic removal during hemoadsorption and continuous kidney support in the ICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll about 20 adult ICU patients with septic shock and renal failure requiring continuous renal replacement therapy (CRRT) who are receiving meropenem, linezolid, or daptomycin. A single Jafron HA380 hemoadsorption cartridge will be placed in series with a BBraun OMNI PLUS open CVVHD filter for 2–12 hours while standard citrate anticoagulation is used. Blood samples will be drawn before the cartridge, immediately after the cartridge, and after treatment and analyzed by liquid chromatography–tandem mass spectrometry to measure antibiotic concentrations. The goal is to quantify how much of each antibiotic is removed during passage through the hemoadsorption cartridge and CRRT circuit over a 12-month enrollment window.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* stage 3 KDIGO consensus criteria, indication to CRRT
* use of at least one of the following antibiotics meropenem, linezolid and daptomycin
* \< 18 yo

Exclusion Criteria:

* \< 18 yo

Where it's running

• Niguarda Hospital
  Milan, Italia, Italy Recruiting

Study contacts

• Principal investigator: Sara Micol Santambrogio, MD — Niguarda Hospital
• Study coordinator: Sara Micol Santambrogio, MD
• Email: saramicol.santambrogio@ospedaleniguarda.it
• Phone: +390264441

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.