Understanding heart cell problems in children with severe infections
Mechanisms of cardiomyocyte dysfunction in pediatric septic shock
['FUNDING_CAREER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11007260
This study is looking at how severe infections can affect the heart cells of children in septic shock, and it aims to use heart cells from these kids to better understand why some have heart problems during their illness.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11007260 on ClinicalTrials.gov |
What this research studies
This research investigates how heart cells, known as cardiomyocytes, are affected during severe infections in children, specifically those experiencing septic shock. The team aims to create a model using heart cells derived from patients to better understand the biological mechanisms behind heart dysfunction in these cases. By analyzing serum samples from children with and without heart dysfunction, the researchers hope to identify factors that contribute to these issues. This approach focuses on using patient-derived materials to improve the relevance of findings to human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are experiencing septic shock.
Not a fit: Patients who are not experiencing septic shock or are over 11 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart dysfunction in children suffering from septic shock.
How similar studies have performed: Previous research has shown promise in using patient-derived models to study heart dysfunction, indicating potential for success in this novel approach.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAUTZ, ANDREW JOHN — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: LAUTZ, ANDREW JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.