oXiris hemofilter use for adults with septic shock and kidney failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter retrospective cohort study that uses a Target Trial Emulation framework to mimic a randomized comparison of CRRT started with the oXiris filter versus standard CRRT filters. Time zero is defined as CRRT initiation in ICU adults with septic shock and AKI, and outcomes include in-hospital mortality, fluid balance, and vasopressor requirements. Data come from five major South Korean medical centers and the Korea Sepsis Alliance registry, with IPTW used to adjust for baseline confounding and confounding by indication. The analysis covers patients treated between March 2021 and August 2025 and excludes early deaths, ESRD, and records with critical missing covariates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 19 years or older.
* Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025.
* Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI).

Exclusion Criteria:

* Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission.
* Patients with End-Stage Renal Disease (ESRD).
* Patients with missing critical covariates.

Where it's running

• Seoul National University Bundang Hospital
  Seongnam-si, Gyeonggi-do, South Korea Recruiting

Study contacts

• Principal investigator: Sung Yoon Lim, MD.PhD — Seoul National University Bundang Hospital
• Study coordinator: Sung Yoon Lim, MD. PhD
• Email: nucleon727@snu.ac.kr
• Phone: 82+1028469179

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

• Personalized Fluid Resuscitation in the Emergency Department

  This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.

  Recruiting Intermountain Health Care, Inc. · Murray, Utah · NCT07779720

• Discordance between capillary refill time and oxygen use in septic shock

  This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07774962

• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

• Cortisol Levels and Mortality in Septic Shock ICU Patients

  This study tests whether cortisol levels can predict death or recovery in adults with sepsis or septic shock in the ICU.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07582926

• Adjunctive Fludrocortisone in Septic Shock

  This study tests adding fludrocortisone to usual care for adults with septic shock to see if it helps patients survive and recover better.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong and 4 other locations · NCT07451886

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.