Biomarkers of Inflammation, Infection, and Immunity in Critically Ill Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

MARINA is an observational study that collects biomarker data from adults in critical care to see how inflammatory and immune markers relate to disease severity, organ damage, treatment response, and infectious complications. It includes patients with suspected or confirmed infections, those undergoing high-risk major surgery, and immunocompromised individuals. The study uses serial measurements of both established and emerging biomarkers, such as procalcitonin and C-reactive protein, to explore prognostic patterns. Data are gathered from multiple centers, combining prospective and retrospective elements to understand relationships between biomarkers and clinical outcomes. Interventions are not part of the protocol; the study focuses on observational associations to inform future risk assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Written informed consent to participate in the study (or deferred consent, obtained as soon as clinically feasible, in patients unable to provide consent at the time of enrollment)
* Surgical group: patients who have undergone a high-risk elective or emergency surgical procedure under general anesthesia within the previous 24 hours (cardiac surgery, thoracic surgery, abdominal surgery)
* Infection group: suspected or confirmed infection (including sepsis and septic shock), either community- or hospital-acquired
* Immunocompromised group (subset of the infection group): patients with impaired immune status, including solid organ transplant (SOT) recipients, hematopoietic stem cell transplant (HSCT) recipients, bone marrow transplant recipients, CAR-T cell therapy recipients, or any other form of severe immunosuppression

Exclusion Criteria:

* Refusal to provide informed consent
* Age \< 18 years
* Pregnancy
* Therapeutic limitations or clinical decision to withdraw or withhold life-sustaining treatment at the time of enrollment

Where it's running

• AOU Città della Salute e della Scienza
  Torino, Italy Recruiting

Study contacts

• Study coordinator: Giorgia Montrucchio, Professor
• Email: giorgiagiuseppina.montrucchio@unito.it
• Phone: 00390116331633

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.