Identifying biomarkers for diagnosing sepsis in the emergency room

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the immune responses of patients with and without sepsis who present to the emergency department with suspected infections. It seeks to identify immune response abnormalities that may indicate an increased risk of developing sepsis in patients initially presenting without it. Additionally, the study will assess the long-term cognitive and physical effects of sepsis on patients after their admission. The research will utilize the SOFA score to define sepsis and will adapt the assessment of respiratory function for emergency settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or higher
* Presentation at the Emergency Department (ED)
* Clinical suspicion of infection or earlier confirmed infection
* Modified Early Warning Score (MEWS) of 2 or higher

Exclusion Criteria:

* No informed consent given

Where it's running

• Amsterdam UMC, location VUMC
  Amsterdam, North Holland, Netherlands Recruiting
• Amsterdam UMC, location AMC
  Amsterdam, North Holland, Netherlands Recruiting
• Flevoziekenhuis
  Almere Stad, Flevoland, Netherlands Not yet recruiting

Study contacts

• Principal investigator: Willem Joost Wiersinga, MD, PhD — Amsterdam UMC, location AMC
• Study coordinator: Oren Turgman, MD, MsC
• Email: biosep@amsterdamumc.nl
• Phone: 0205669111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Reducing unnecessary vancomycin use in children with suspected sepsis

  This study is testing a new approach to see if better guidelines and education can help doctors use less vancomycin in children suspected of having sepsis, which could lower the risk of kidney problems.

  Recruiting at 4 sites Children's Hospital of Philadelphia · Atlanta, Georgia and 3 other locations · NCT05975671

• Personalized care approach for patients with suspected sepsis

  This study is testing new ways to diagnose sepsis in about 1500 adults who show signs of it when they arrive at the emergency department, to help create more personalized treatment plans.

  Recruiting Oslo University Hospital · Oslo · NCT04203979

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

• Personalized Fluid Resuscitation in the Emergency Department

  This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.

  Recruiting Intermountain Health Care, Inc. · Murray, Utah · NCT07779720

• Discordance between capillary refill time and oxygen use in septic shock

  This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07774962

• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.