Muscle along the spine on a CT scan to predict 3-month survival after septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study investigates whether quantitative and qualitative muscle measurements from a CT scan at the L3 level, taken near ICU admission, correlate with 3-month mortality in septic shock patients. It builds on prior findings that muscle mass and density relate to outcomes in critical illness, aiming to determine prognostic value in the ICU setting. The study uses non-contrast CT scans and aligns with standard ICU practice while focusing on patients with septic shock. Primary analysis will assess associations between muscle-derived parameters and subsequent mortality, with secondary observations on feasibility and potential clinical implications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients hospitalized in intensive care for septic shock defined by the presence of a documented or suspected infection, plasma lactate \>2 mmol/L, and an increase in SOFA score of more than 2 points from baseline (Singer et al., 2016)

* Patients who underwent a non-contrast CT scan within 48 hours prior to admission and up to 24 hours after admission to intensive care
* Patients affiliated with or eligible for social security

Exclusion Criteria:

* Patients with a neuromuscular disease prior to admission to intensive care.
* Pregnant women
* Patients under guardianship and/or conservatorship
* Refusal of consent.

Where it's running

• Centre Hospitalier Universitaire de Saint-Etienne
  Saint-Etienne, France Recruiting
• Hospices Civils de Lyon
  Lyon, France Not yet recruiting
• AP HM, Hôpital La Timone
  Marseille, France Not yet recruiting
• Clinique Mutualiste
  Saint-Etienne, France Not yet recruiting

Study contacts

• Principal investigator: Nory Elhadjene, MD — Centre Hospitalier Universitaire de Saint Etienne
• Study coordinator: Nory Elhadjene, MD
• Email: nory.elhadjene@gmail.com
• Phone: (0)4.77.82.97.43

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.