Using routine data to improve diagnosis of sepsis and septic shock
Official title: Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome (QUICK-SEPSIS)
Run by Charite University, Berlin, Germany · NCT05383963 · Data updated 2026-11-12
This study is testing a new computer program that uses past medical records to see if it can help doctors diagnose sepsis and septic shock faster and more accurately for patients in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Status | Recruiting |
| Started | July 15, 2022 |
| Main results expected | September 2026 |
| Study ends | December 2027 |
| Registry record updated | December 1, 2025 |
| Trial ID | NCT05383963 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been in the ICU for more than 24 hours.
✕Probably not a fit
Patients who do not meet the age or ICU stay criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes retrospective data from medical records to develop a machine learning algorithm aimed at enhancing the diagnosis of sepsis and septic shock. The study will evaluate how various parameters influence the time to diagnosis and patient outcomes. By focusing on data collected from ICU patients over a 14-year period, the research seeks to validate the predictive value of the algorithm and improve treatment processes. The study will also assess the economic implications of enhanced diagnostic accuracy.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate diagnoses of sepsis, improving patient outcomes and potentially saving lives.
How similar studies have gone: Other studies utilizing machine learning for sepsis diagnosis have shown promise, indicating that this approach could be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \>= 18 years * ICU stay of \> 24 hours Exclusion Criteria: * none
Where it's running
-
Department of Anesthesiology and Operative Intensive Care Medicine CCM/CVK, Charité - Universitätsmedizin Berlin
Berlin, Germany Recruiting
Study contacts
- Study coordinator: Claudia Spies, MD, Prof.
- Email: claudia.spies@charite.de
- Phone: +49 30 450 55 11 02
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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-
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-
Discordance between capillary refill time and oxygen use in septic shock
This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.
-
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This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.
-
Cortisol Levels and Mortality in Septic Shock ICU Patients
This study tests whether cortisol levels can predict death or recovery in adults with sepsis or septic shock in the ICU.
-
oXiris hemofilter use for adults with septic shock and kidney failure
This study tests whether using the oXiris hemofilter during continuous dialysis helps adults with septic shock and acute kidney injury survive and stabilize faster.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.