Carotid Doppler and echocardiography to predict fluid response in children with septic shock
Official title: Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
Run by Ain Shams University · NCT07136532 · Data updated 2026-11-12
We will test whether carotid Doppler ultrasound and echocardiography can tell which children with septic shock will respond to fluid treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Month to 16 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | March 1, 2027 |
| Registry record updated | August 22, 2025 |
| Trial ID | NCT07136532 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 1 month to 16 years with septic shock admitted to the PICU during the fluid resuscitation phase who do not have major cardiac, renal, vascular, or neck anatomical problems.
✕Probably not a fit
Patients with congenital or acquired heart or renal disease, major vascular anomalies, suspected intracranial hypertension, or skin/neck conditions that prevent ultrasound are excluded and unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project enrolls children with septic shock admitted to the PICU and measures clinical, laboratory, and ultrasound parameters during the fluid resuscitation phase. Bedside echocardiography will record stroke volume, stroke volume index, cardiac index, aortic peak velocity, and VTI variation, while carotid Doppler and IVC collapsibility/distensibility indices will also be obtained. Clinical vitals (blood pressure, heart rate, urine output, capillary refill, CVP) and routine labs (blood counts, gases, lactate, CRP, kidney function, albumin, fibrinogen) are collected before and after fluid resuscitation. The imaging and clinical data will be compared to determine which measures best predict fluid responsiveness in children aged 1 month to 16 years.
Why it matters
Potential benefit: If successful, this could help doctors give the right amount of fluid to children with septic shock and reduce harm from under- or over-resuscitation.
How similar studies have gone: Similar Doppler and echocardiographic measures have shown promise for predicting fluid responsiveness in adults and in small pediatric series, but robust pediatric evidence is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria : * Children aged 1 month to 16 years. * Patients with septic shock admitted at the PICU during their fluid resuscitative phase were included.Septic shock was diagnosed according to phoenix sepsis score 2024 • Exclusion criteria: * Acquired and congenital heart disease. * Acquired and congenital renal disease. * Vascular anomalies (e.g. arteriovenous malformation, aneurysm). * Suspected intracranial hypertension. * Skin lesions or bandages at the sites of ultrasound or echo-cardiography examinations. * Anatomical anomalies of the neck.
Where it's running
-
Ain shams university _faculty of medicine
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Sara sobhy selim, assistant lecturer
- Email: SaraSobhy@med.asu.eg
- Phone: +2001008668418
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.