Investigating the use of hydrocortisone in treating pediatric septic shock
SHIPSS: Stress Hydrocortisone In Pediatric Septic Shock
This study is looking at how hydrocortisone can help children with septic shock feel better and recover faster, especially for those who might have trouble with their adrenal glands.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10906011 on NIH RePORTER |
What this research studies
This research focuses on the use of hydrocortisone as an adjunct therapy for children experiencing septic shock, a severe condition that can lead to high mortality rates. The study aims to rigorously evaluate the benefits and risks of hydrocortisone treatment in pediatric patients, particularly those at risk of adrenal insufficiency. By analyzing patient responses and outcomes, the research seeks to determine how hydrocortisone can improve recovery and quality of life for affected children. The methodology includes clinical assessments and monitoring of health-related quality of life over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who are diagnosed with septic shock and may be at risk for adrenal insufficiency.
Not a fit: Patients who do not have septic shock or those who are not at risk for adrenal insufficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for pediatric septic shock, potentially reducing mortality and enhancing recovery for children.
How similar studies have performed: Previous research has shown that corticosteroids can improve hemodynamic status in sepsis, suggesting potential for success in this novel application for pediatric patients.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Agus, Michael Sd — Boston Children's Hospital
- Study coordinator: Agus, Michael Sd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.