Condition

Cirrhosis, Liver clinical trials and research

• 37Clinical trials
• 13Countries

Newest Cirrhosis, Liver clinical trials

All recruiting trials (37)

• Bile acid and gut microbiota changes in people with hepatitis D starting bulevirtide

  This project will see if starting bulevirtide changes bile acids and gut bacteria in adults with chronic hepatitis D who are already on hepatitis B therapy.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07429864

• Diagnosing lymphohistiocytic hemophagocytosis in intensive care patients with liver disease

  This study will test whether the HScore can accurately detect lymphohistiocytic hemophagocytosis in adults with hepatocellular insufficiency or cirrhosis admitted to intensive care.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07343037

• Echocardiography-guided intensive care for septic shock in people with cirrhosis

  This study will try using bedside ultrasound (POCUS) to guide fluid and blood-pressure treatment in adults with cirrhosis who develop sepsis-related low blood pressure.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT07286643

• Understanding social and health needs of people with chronic liver disease in outpatient care

  This project will see how common social needs are and whether adults with chronic liver disease want their outpatient providers to help with them.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07191886

• Non-invasive blood and imaging tests for metabolic liver disease

  This project tests whether blood tests and imaging scans can diagnose and stage metabolic-associated steatohepatitis (MASH) and liver fibrosis in adults with metabolic risk factors.

  Recruiting at 4 sites Foundation for the National Institutes of Health · Miami, Florida and 3 other locations · NCT07122700

• High-protein, plant-dominant diet for people with liver cirrhosis

  This 6-month test compares a high-protein, mostly plant-based diet to a usual low-fat animal-protein diet in adults with decompensated cirrhosis who are awaiting kidney transplant to see which better preserves nutrition and muscle.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07028580

• Assessing diabetes risk in cirrhosis patients before and after liver transplant

  This study is trying to find out what factors might lead to diabetes in adults with liver cirrhosis before and after they get a liver transplant.

  Recruiting University of Chicago · Chicago, Illinois · NCT06950788

• Using ROTEM to assess bleeding risk in cirrhosis patients after procedures

  This study is testing if a special blood test called ROTEM can help doctors predict bleeding risks in patients with cirrhosis who are having high-risk procedures.

  Recruiting at 11 sites Instituto de Investigación Marqués de Valdecilla · Santander, Cantabria and 10 other locations · NCT06908785

• Microbiota augmentation to restore healthy gut bacteria in hospitalized liver patients

  This trial will test whether giving defined groups of healthy gut bacteria is safe and can restore key gut metabolites in hospitalized adults with liver disease who have low fecal butyrate and deoxycholic acid.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT06871111

• Treatment for advanced liver cancer with specific cirrhosis

  This study is testing a new combination treatment for advanced liver cancer in patients with specific cirrhosis to see if it can help them better than current options, especially focusing on those from underserved communities.

  Recruiting Phase 2 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06526104

• Evaluating fluid treatment strategies for kidney injury in cirrhosis patients

  This study is testing two different ways to give IV fluids to people with kidney injury and cirrhosis to see which method helps them feel better and survive longer.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06525623

• Using Siplizumab to prevent immune issues in liver transplant patients with autoimmune liver disease

  This study is testing if a new medication called siplizumab can help prevent immune problems in adults with autoimmune liver disease who are getting a liver transplant.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06455280

• Carvedilol plus simvastatin versus carvedilol alone for cirrhosis-related heart dysfunction

  This trial will test whether adding simvastatin to carvedilol helps adults with cirrhosis and cirrhotic cardiomyopathy reduce liver decompensation and improve survival.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT06431919

• Using sulfasalazine to treat liver fibrosis and cirrhosis.

  This study is testing if the medication sulfasalazine can help improve liver function and health in people with different types of cirrhosis.

  Recruiting at 2 sites The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality and 1 other locations · NCT06293378

• Program to help patients with cirrhosis manage fluid overload after hospital discharge

  This study tests a new program that helps patients with cirrhosis manage swelling from fluid overload after leaving the hospital to see if it can reduce hospital visits and improve their health.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06174272

• Using EGCG to prevent liver cancer in patients with cirrhosis

  This study is testing if a supplement called EGCG can help prevent liver cancer in people who have cirrhosis.

  Recruiting Phase 2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06015022

• Effects of exercise on patients with cirrhosis

  This study tests if a 12-week exercise program can help people with cirrhosis gain muscle and feel healthier.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05982769

• Improving early diagnosis of liver cancer in high-risk patients in China

  This study is testing if regular check-ups for liver cancer can help catch the disease earlier in people at high risk due to conditions like chronic hepatitis or cirrhosis in China.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT05870969

• Evaluating rosuvastatin for treating liver cirrhosis

  This study is testing if the medication rosuvastatin can help improve liver health in people with compensated cirrhosis over a period of 96 weeks.

  Recruiting at 13 sites Phase 2 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · La Jolla, California and 12 other locations · NCT05832229

• Evaluating nutrition in patients with cirrhosis

  This study looks at how cirrhosis affects nutrition in patients and tests if branched-chain amino acids can help improve their health.

  Recruiting SUUMC Central Military Hospital Dr Carol Davila · Bucharest, București - Sector1 · NCT05729438

• Understanding liver disease linked to alcohol and metabolic syndrome

  This study is trying to find out what causes liver cancer in people with alcohol-related liver disease and fatty liver disease by looking at their health, diet, and immune system over several years.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Nice · NCT05623150

• Evaluating PHIN-214 for treating liver cirrhosis

  This study is testing a new treatment called PHIN-214 to see if it can safely help people with liver cirrhosis improve their liver function and manage related health issues.

  Recruiting at 9 sites Phase 1 PharmaIN · Chandler, Arizona and 8 other locations · NCT05490888

• Using 3D-MRE to assess liver disease and portal hypertension

  This study is testing if a new type of imaging called 3D-MRE can help doctors better understand and manage portal hypertension in patients with cirrhosis and advanced liver disease.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT05475015

• CT-guided localization for small liver tumors before surgery

  This study tests if using a special needle to pinpoint small liver tumors with CT scans before surgery can help doctors remove them more accurately for patients with cirrhosis.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05433467

• TIPS treatment for patients with cirrhosis and acute kidney injury

  This study is testing if a procedure called TIPS can help people with liver cirrhosis and kidney problems feel better compared to standard treatments.

  Recruiting at 10 sites Jena University Hospital · Aachen and 13 other locations · NCT05346393

• Laparoscopic surgery to improve immune function in cirrhosis patients

  This study is testing if a specific type of surgery can help boost the immune system in people with liver cirrhosis who have an enlarged spleen.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05338294

• Surgery to improve liver function in cirrhosis patients

  This study tests whether a specific surgery can help improve liver function in patients with cirrhosis who have an enlarged spleen.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05325437

• Laparoscopic splenectomy's effect on liver function in cirrhosis patients

  This study tests if a minimally invasive surgery to remove the spleen can improve liver function in patients with cirrhosis.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05325424

• Using HMB and amino acids to improve muscle loss in cirrhosis

  This study is testing if a combination of HMB and amino acids can help people with cirrhosis build muscle and improve their health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05166499

• Using danazol to treat blood cell deficiencies in patients with cirrhosis

  This study is testing if the medication danazol can help improve blood cell counts in people with cirrhosis who have low levels of red or white blood cells.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT04873102

• Registry of hospitalized patients with liver cirrhosis

  This study is collecting information from adults hospitalized with liver cirrhosis to better understand their health outcomes and complications after they leave the hospital.

  Recruiting F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica · Banská Bystrica · NCT04767945

• Comparing 2-dose and 3-dose hepatitis B vaccine regimens in cirrhosis patients

  This study is testing whether giving two or three doses of the hepatitis B vaccine works better for people with cirrhosis who need protection against the virus.

  Recruiting Phase 4 Mercy Medical Center · Baltimore, Maryland · NCT04588077

• Does high abdominal pressure cause microaspiration in ventilated patients with cirrhosis?

  We will see if high pressure inside the belly leads to more microaspiration in adults with cirrhosis who are on mechanical ventilation.

  Recruiting at 2 sites University Hospital, Lille · Lille and 1 other locations · NCT04530760

• Comparing nutritional screening tools for liver cirrhosis patients

  This study is testing two special questionnaires to see which one better helps find malnutrition in people with liver cirrhosis.

  Recruiting Hospital Clinic of Barcelona · Barcelona, Catalonia · NCT04502719

• Improving care for patients with liver cirrhosis in Alberta

  This study is testing a new program to improve care for people with liver cirrhosis in Alberta to help them stay healthier and reduce hospital visits.

  Recruiting University of Alberta · Edmonton, Alberta · NCT04149223

• Preventing liver complications after TIPS placement with rifaximin and lactulose

  This study is testing if taking rifaximin and lactulose can help prevent brain problems in adults with liver cirrhosis after they have a procedure called TIPS.

  Recruiting at 6 sites Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Leuven and 5 other locations · NCT04073290

• Using leucine to reverse muscle loss in cirrhosis

  This study is testing if a special mixture of amino acids, including leucine, can help people with cirrhosis regain lost muscle and improve their strength.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT03208868

Related topics

Quick answers

How many Cirrhosis, Liver clinical trials are recruiting right now?

37, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (16 trials), China (7 trials), France (3 trials), India (2 trials), Spain (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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