Atrial strain measurement in people with septic shock.
Assessment of Left And Right Atrial Strain in Septic Shock
This project tests whether two echocardiography software packages and an AutoStrain tool give similar left and right atrial strain results using past heart ultrasound scans from adults treated for septic shock.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Salouël) |
| Trial ID | NCT06832436 on ClinicalTrials.gov |
What this trial studies
This retrospective, non-interventional study will re-analyze transthoracic echocardiograms obtained from adults treated for septic shock to compare left and right atrial strain measurements. Measurements will be performed using two software packages (ECHOPAC and UWS) and with AutoStrain technology, and multiple observers will repeat analyses to assess reproducibility. Exclusion criteria include poor image quality, significant valvular disease, high-rate arrhythmia at the time of imaging, mechanical circulatory support, or pacemaker dependence. The goal is to identify measurement differences between platforms and improve standardization of atrial strain assessment in critically ill patients.
Who should consider this trial
Good fit: Ideal candidates are adult ICU patients (>18 years) who had a transthoracic echocardiogram recorded during treatment for septic shock and who do not have major valvular disease, uncontrolled arrhythmia, mechanical circulatory support, or pacemaker dependence.
Not a fit: Patients without usable TTE images, with poor echogenicity, with significant valvular disease or fast arrhythmias at the time of imaging, or those on mechanical support or pacemaker-dependent are unlikely to benefit from the findings.
Why it matters
Potential benefit: If successful, the work could make atrial strain measurements more reliable and comparable across hospitals, helping clinicians interpret echocardiograms more consistently in septic shock.
How similar studies have performed: Prior research has shown that atrial strain by speckle-tracking has prognostic value in cardiac disease, but direct comparisons between software platforms and AutoStrain validation specifically in septic shock are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: \>18 years * Adult patients admitted to critical care for septic shock (SEPSIS-3 definition) * TTE performed as part of medical management * No objection to data usage Exclusion Criteria: * Pregnancy * Moderate to severe valvular regurgitation/stenosis (\>grade 2) * Ventricular or supraventricular tachyarrhythmia (HR \>140 bpm) at the time of TTE * Poor echogenicity preventing LAS measurement * Mechanical circulatory support * Pacemaker dependence * Patients under guardianship
Where this trial is running
Salouël
- CHRU Amiens — Salouël, France (Recruiting)
Study contacts
- Study coordinator: Christophe Beyls, MD
- Email: beyls.christophe@chu-amiens.fr
- Phone: 33+322087866
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.