Reducing unnecessary vancomycin use in children with suspected sepsis
Official title: Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis (REVAMP-Sepsis)
Run by Children's Hospital of Philadelphia · NCT05975671 · Data updated 2026-11-12
This study is testing a new approach to see if better guidelines and education can help doctors use less vancomycin in children suspected of having sepsis, which could lower the risk of kidney problems.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 52500 (estimated) |
| Sponsor | Children's Hospital of Philadelphia Academic / other |
| Locations | 4 sites (Atlanta, Georgia and 3 other locations) |
| Status | Recruiting |
| Started | August 21, 2023 |
| Main results expected | May 2026 |
| Study ends | May 2026 |
| Registry record updated | September 19, 2025 |
| Trial ID | NCT05975671 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pediatric patients admitted to participating PICUs with suspected sepsis.
✕Probably not a fit
Patients who are not admitted to the participating PICUs or those with confirmed infections that do not require vancomycin may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study aims to evaluate the effectiveness of a multifaceted stewardship intervention designed to reduce the use of vancomycin in pediatric intensive care units (PICUs). The intervention includes the implementation of clinical guidelines, unit-level feedback on vancomycin use, and clinician education. By analyzing electronic health record data, the study will assess vancomycin use and associated infections over a 24-month baseline period, followed by a 24-month post-intervention period. The goal is to minimize inappropriate vancomycin prescriptions and reduce the risk of acute kidney injury in pediatric patients.
Why it matters
Potential benefit: If successful, this intervention could significantly decrease the incidence of preventable kidney injuries in children treated for suspected sepsis.
How similar studies have gone: Other studies have shown success in implementing antibiotic stewardship programs, indicating that this approach has potential for effectiveness.
Who can join: the full rules
Show full inclusion / exclusion criteria
Patient Inclusion Criteria: * Admitted to one of the participating PICUs during the study period Patient Exclusion Criteria: * None Clinician Inclusion Criteria: 1. PICU prescribing clinician (including attending physicians, fellows, residents, nurse practitioners, and physician assistants) OR sepsis stakeholder (leader of sepsis quality improvement work, medical director) at one of the participating sites at the time the survey is deployed 2. Age ≥ 18 years old 3. Employed by one of the participating sites Clinician Exclusion Criteria: 1. Volunteers or other non-employee hospital staff 2. Limited English proficiency
Where it's running
-
Children's Healthcare of Atlanta
Atlanta, Georgia, United States Recruiting -
Johns Hopkins Children's Center
Baltimore, Maryland, United States Recruiting -
St. Louis Children's Hospital
St Louis, Missouri, United States Recruiting -
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Kathleen Chiotos, MD, MSCE — Children's Hospital of Philadelphia
- Study coordinator: Kathleen Chiotos, MD, MSCE
- Email: chiotosk@chop.edu
- Phone: 215-590-5505
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.