Evaluating metabolite supplementation to improve mitochondrial function in septic shock patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of exogenous metabolites on mitochondrial function in patients experiencing septic shock, a critical condition characterized by severe metabolic alterations and high mortality rates. Patients admitted to the medical ICU at Angers University Hospital will have their blood samples collected and analyzed at various time points to assess mitochondrial metabolism and function. The study aims to correlate these metabolic changes with clinical outcomes, including survival and the need for intensive care support. The research will focus on patients meeting specific criteria for septic shock as defined by the SEPSIS-3 guidelines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients aged 18 or more
* Patients with criteria for septic shock according to SEPSIS 3 definition (presumed sepsis, with persisting hypotension requiring vasopressors to maintain mean arterial pressure \> 65 mmHg and having a serum lactate \> 2 mmol/L despite adequate fluid expansion).
* Admitted in the ICU of Angers University Hospital

Exclusion Criteria:

* Minor patients (aged less 18)
* Patient subject to legal protection measures
* Refusal of the patient or his family
* Preexisting mitochondrial disease
* Patient with aplasia
* Pregnant or parturient women

Where it's running

• Chu
  Angers, Maine et Loire, France Recruiting

Study contacts

• Principal investigator: Julien DEMISELLE, MD — University Hospital of Angers
• Study coordinator: Julien DEMISELLE, MD
• Email: Julien.Demiselle@chu-angers.fr
• Phone: +33 2 41 35 58 65

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.