Using Shenfu Injection to Protect Heart Function in Septic Shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of Shenfu Injection, a traditional Chinese medicine, in preventing heart dysfunction in patients experiencing septic shock. The study aims to determine if adding this injection to standard treatment can enhance cardiac function, accelerate recovery, and improve survival rates. It is a multicenter, randomized controlled trial comparing outcomes between patients receiving standard care alone and those receiving standard care plus Shenfu Injection. The trial focuses on patients diagnosed with septic shock according to Sepsis 3.0 criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Patients clinically diagnosed with septic shock must meet the diagnostic criteria of Sepsis 3.0;
* 2\. Age ≥ 18 years.

Exclusion Criteria:

* 1\. Pregnant or breastfeeding women;
* 2\. Individuals with a history of allergies or known hypersensitivity to Ginseng and Aconite Injection or its components;
* 3\. Severe underlying diseases that may affect prognosis, including uncontrolled malignant tumors with multiple metastases that are unresectable, hematological disorders, cachexia, persistent active bleeding, severe malnutrition, HIV, etc.;
* 4\. Severe cardiac conditions within the last three months, including acute unstable myocardial infarction, dilated cardiomyopathy, acute coronary syndrome, acute or chronic valvular heart disease, and congestive heart failure (New York Heart Association \[NYHA\] Class IV);
* 5\. Any of the following medical procedures performed within the last three months: any form of cardiac surgery, thoracotomy, external cardiac compression, defibrillation, direct current cardioversion, or trauma;
* 6\. Use of Ginseng and Aconite Injection for less than 48 hours;
* 7\. Patients expected to die within 48 hours;
* 8\. Patients deemed unsuitable for this study by the investigator.

Where it's running

• The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
  Wuhu, Anhui, China Recruiting

Study contacts

• Study coordinator: Qiancheng Xu
• Email: qianchengxu@wnmc.edu.cn
• Phone: 86-18297529106

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.