Evaluating frailty as a risk factor for mortality in young patients with septic shock
Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.
This study is trying to see if being frail affects the chances of survival for young adults in intensive care with septic shock.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Centre Hospitalier de Lens Academic / other |
| Locations | 5 sites (Béthune and 4 other locations) |
| Trial ID | NCT05928767 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the impact of clinical frailty, measured by the Clinical Frailty Scale (CFS), on mortality rates among adult patients aged 18 to 65 years admitted to intensive care for septic shock. It will categorize patients based on their CFS scores, identifying those who are 'frail' or 'severely frail' as potential independent risk factors for mortality. Additionally, the study will explore the relationship between frailty and outcomes such as length of hospital stay, readmission rates, and quality of life. The findings aim to enhance understanding of frailty's implications in critically ill patients and improve clinical decision-making.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 65 years who are admitted to intensive care for septic shock and meet specific clinical criteria.
Not a fit: Patients who are moribund on admission or have severe cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better prognostic assessments and tailored care strategies for young patients with septic shock.
How similar studies have performed: While there is limited research specifically targeting frailty in younger patients with septic shock, existing studies have indicated frailty as a significant risk factor in critical care settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥18 years and ≤ 65 years * Patient admitted to intensive care - resuscitation * Patient admitted for suspected or documented type 3 sepsis * Presence of vasopressor amines to maintain MAP \> 65mmHg despite filling * Lactatemia ≥ 2 mmol/L on admission. Exclusion Criteria: * Patient moribund on admission * Patients with severe pre-existing dementia and/or cognitive decline, suffering from severe neurodegenerative diseases that prevent the patient from living independently at baseline, including mental illness requiring institutionalisation, including acquired or congenital mental retardation, etc. * Pregnant women or women in labour * Patients under guardianship or curatorship * Patients deprived of their liberty * Patient and/or family unable to speak or understand French.
Where this trial is running
Béthune and 4 other locations
- Ch Germon Et Gauthier — Béthune, France (Recruiting)
- CH Boulogne sur Mer — Boulogne-sur-Mer, France (Recruiting)
- CHU de Dijon — Dijon, France (Recruiting)
- CH de Lens — Lens, France (Recruiting)
- CHU Lille — Lille, France (Recruiting)
Study contacts
- Study coordinator: Guillaume DEGOUY, Dr
- Email: gdegouy@ch-lens.fr
- Phone: 03.21.69.12.34
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.