Understanding how different patients respond to septic shock treatment
Official title: Informing the Emergency Care of Septic Shock Patients: A Novel Application of Data-Driven Analytics
Funded at Northwestern University at Chicago · NIH-11081820 · Data updated 2026-11-12
This study is looking at how different people with septic shock respond to treatments, focusing on their unique traits and genetics, to help find better and more personalized ways to help everyone recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 20, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $176,990 |
| NIH project number | 5K23GM144802-04 |
| Project ID | NIH-11081820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with septic shock, particularly those from diverse racial backgrounds.
✕Less likely to help
Patients who do not have septic shock or those with other unrelated medical conditions may not benefit from this research.
What this research studies
This research investigates the varying responses of patients with septic shock to treatments, focusing on both clinical and genetic factors. By utilizing advanced data analytics, the study aims to identify distinct patient phenotypes and the genetic variations that may influence treatment outcomes. The goal is to enhance the understanding of why some patients respond better to certain therapies than others, particularly among different racial groups. This research could lead to more personalized and effective treatment strategies for septic shock patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that significantly reduce mortality rates in septic shock patients.
How similar studies have gone: Other research has shown promise in using advanced analytics to improve patient outcomes in critical care settings, suggesting that this approach could yield valuable insights.
Where this research is happening
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Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Black, Lauren Page — Northwestern University at Chicago
- Study coordinator: Black, Lauren Page
Related research
Other NIH-funded projects on the same topics.
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Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
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Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
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Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
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Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
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Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
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Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.