Understanding blood transfusions in children with septic shock
Transfusion and Organ Dysfunction in Pediatric Septic Shock (TROPICS) study
['FUNDING_R01'] · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · NIH-11055300
This study is looking at how red blood cell transfusions can help children with septic shock, and it aims to find out which kids might benefit the most from these transfusions by looking at different health factors, so we can make better decisions about their treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST NATIONWIDE CHILDREN'S HOSP (nih funded) |
| Locations | 1 site (COLUMBUS, UNITED STATES) |
| Trial ID | NIH-11055300 on ClinicalTrials.gov |
What this research studies
This research investigates how red blood cell (RBC) transfusions affect children suffering from septic shock, a severe condition that can lead to organ dysfunction. The study aims to identify which children are most likely to benefit from transfusions by analyzing various physiological and blood product factors, rather than relying solely on hemoglobin levels. By developing decision support tools, the research seeks to personalize transfusion strategies to improve outcomes for pediatric patients. The approach includes collecting data on hemodynamic measures and the characteristics of blood products used in transfusions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are experiencing septic shock.
Not a fit: Patients who are not experiencing septic shock or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective blood transfusion practices for children with septic shock, potentially reducing adverse outcomes.
How similar studies have performed: Previous research has indicated that personalized approaches to transfusion can improve patient outcomes, suggesting that this study builds on established findings.
Where this research is happening
COLUMBUS, UNITED STATES
- RESEARCH INST NATIONWIDE CHILDREN'S HOSP — COLUMBUS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSZYNSKI, JENNIFER — RESEARCH INST NATIONWIDE CHILDREN'S HOSP
- Study coordinator: MUSZYNSKI, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.