Studying lactate levels in patients with septic shock
Lactate Kinetics in Patients Treated for Septic Shock
NA · Karolinska University Hospital · NCT05349370
This study is testing how lactate levels change in adults with septic shock in the ICU to see if it can help us understand their condition better and improve their care.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska University Hospital (other) |
| Locations | 1 site (Stockholm, Stockholm County) |
| Trial ID | NCT05349370 on ClinicalTrials.gov |
What this trial studies
This study investigates lactate kinetics in adult patients diagnosed with septic shock who are admitted to the Intensive Care Unit. Participants will receive a bolus injection of stable isotopically labeled lactate, followed by multiple blood samples taken over a two-hour period to analyze lactate production and consumption. The goal is to better understand the metabolic processes involved in sepsis and how lactate levels correlate with patient outcomes. The study aims to recruit patients within 72 hours of symptom onset to ensure timely data collection.
Who should consider this trial
Good fit: Ideal candidates are adults over 17 years old who have been diagnosed with sepsis and have an arterial catheter in place.
Not a fit: Patients with mitochondrial defects, degenerative muscle diseases, or terminal liver failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment strategies for patients suffering from septic shock.
How similar studies have performed: While studies on lactate kinetics exist, this specific approach using isotopically labeled lactate in septic patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sepsis * Age \>17 years * Arterial catheter * Lactate \> 2 mmol at any time point prior to inclusion Exclusion Criteria: * Mitochondrial defect * Degenerative muscle disease * Terminal liver failure
Where this trial is running
Stockholm, Stockholm County
- Karolinska University Hospital — Stockholm, Stockholm County, Sweden (RECRUITING)
Study contacts
- Study coordinator: Jonathan Grip, MD, PhD
- Email: jonathan.grip@regionstockholm.se
- Phone: +46736230906
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Sepsis, Septic Shock