Studying lactate levels in patients with septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates lactate kinetics in adult patients diagnosed with septic shock who are admitted to the Intensive Care Unit. Participants will receive a bolus injection of stable isotopically labeled lactate, followed by multiple blood samples taken over a two-hour period to analyze lactate production and consumption. The goal is to better understand the metabolic processes involved in sepsis and how lactate levels correlate with patient outcomes. The study aims to recruit patients within 72 hours of symptom onset to ensure timely data collection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Sepsis
* Age \>17 years
* Arterial catheter
* Lactate \> 2 mmol at any time point prior to inclusion

Exclusion Criteria:

* Mitochondrial defect
* Degenerative muscle disease
* Terminal liver failure

Where it's running

• Karolinska University Hospital
  Stockholm, Stockholm County, Sweden Recruiting

Study contacts

• Study coordinator: Jonathan Grip, MD, PhD
• Email: jonathan.grip@regionstockholm.se
• Phone: +46736230906

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.