Personalized treatment for septic shock using vasopressors
Official title: Personalized vasopressor therapy in patients with septic shock
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10914810 · Data updated 2026-11-12
This study is looking at how different people with septic shock respond to blood pressure medications, using smart technology to create personalized tools that help doctors choose the best treatment for each patient to improve their chances of recovery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $177,281 |
| NIH project number | 5K08GM147806-03 |
| Project ID | NIH-10914810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with septic shock who require vasopressor therapy.
✕Less likely to help
Patients who do not have septic shock or those who are not candidates for vasopressor therapy may not benefit from this research.
What this research studies
This research focuses on improving the treatment of septic shock, a severe condition with a high mortality rate. It aims to understand how individual patient characteristics affect their response to vasopressor medications, which are critical for managing blood pressure in these patients. By utilizing machine learning techniques, the project seeks to develop personalized tools that can predict how well a patient will respond to different vasopressors, ultimately aiming to enhance treatment outcomes. The research will also explore how to effectively implement these predictive models in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored vasopressor therapies for patients with septic shock, potentially reducing mortality rates.
How similar studies have gone: Other research has shown promise in using personalized medicine approaches for critical care, suggesting that this innovative method could lead to significant advancements.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Bauer, Seth — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Bauer, Seth
Related research
Other NIH-funded projects on the same topics.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
-
Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
-
Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
-
Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
-
Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.