VEXUS Score in Septic Shock: Can It Predict Mortality
Official title: Prognostic Power of the VEXUS Score in Septic Shock: Efficacy in Mortality Prediction
Run by Antalya Training and Research Hospital · NCT07124741 · Data updated 2026-11-12
This study tests whether the VEXUS score measured early in septic shock can help predict which patients are more likely to die.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Antalya Training and Research Hospital Government |
| Locations | 1 site (Antalya) |
| Status | Recruiting |
| Started | March 30, 2026 |
| Main results expected | November 30, 2026 |
| Study ends | December 20, 2026 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT07124741 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with septic shock admitted to the ICU who can provide informed consent.
✕Probably not a fit
Patients with conditions that preclude reliable ultrasound assessment or those with contraindications to imaging will be less likely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll adults with septic shock in the ICU and measure the VEXUS score at 0-4 hours, 12-24 hours, and 72 hours after shock onset. Data collected include hemodynamics, fluids and vasopressor use, renal support, ventilation, lab markers of infection, and survival status. Treatments will follow standard ICU protocols, and the study will correlate VEXUS grades with mortality and key clinical outcomes. The aim is to determine if the VEXUS score provides prognostic information beyond routine care.
Why it matters
Potential benefit: If successful, the VEXUS score could help clinicians identify patients at higher risk of death and tailor management accordingly.
How similar studies have gone: Prior ultrasound-based congestion scoring has shown prognostic value in critical illness, but this exact VEXUS approach in septic shock is being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age\>18 * Patients monitored for septic shock in intensive care unit * Signed informed consent Exclusion Criteria: * Age \<18 * Severe obesity precluding adequate ultrasonographic imaging. * Patients in whom venous structures cannot be clearly assessed via ultrasonography due to anatomical or technical reasons (e.g., adhesions following abdominal surgery). * Patients receiving dialysis due to chronic kidney disease or initiating dialysis for acute kidney failure. * Chronic heart failure. * Patients with advanced valvular insufficiency or advanced pulmonary hypertension. * Patients with portal hypertension or advanced-stage liver cirrhosis. * Presence of acute or chronic thrombosis in the inferior vena cava or other venous structures within the scoring area. * Refusal to participate
Where it's running
-
Antalya Training and Research Hospital
Antalya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Nilgun Kavrut Ozturk, Professor
- Email: kavrut@yahoo.com
- Phone: +905334196049
Similar studies
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This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.
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This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.