How platelets and mast cells affect blood vessel problems in septic shock.
Platelet- mast cell interactions as determinants of the vascular pathology in septic shock.
This study is looking at how platelets and mast cells work together to cause problems with blood vessels during septic shock, which could help us find better ways to treat patients and improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10932132 on NIH RePORTER |
What this research studies
This research investigates the interactions between platelets and mast cells to understand how they contribute to blood vessel issues during septic shock. By using advanced imaging techniques, the study aims to identify the cellular mechanisms that lead to severe drops in blood pressure and other vascular complications in patients experiencing septic shock. The researchers will explore how platelets stimulate mast cells, which may play a crucial role in the development of these complications. This work could lead to new insights into the treatment of septic shock and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with septic shock who are experiencing severe vascular complications.
Not a fit: Patients with septic shock who do not exhibit significant vascular pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or prevent vascular complications in patients with septic shock.
How similar studies have performed: Previous research has shown that understanding cellular interactions in vascular pathology can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Abraham, Soman N — Duke University
- Study coordinator: Abraham, Soman N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.