How platelets and mast cells affect blood vessel problems in septic shock.
Official title: Platelet- mast cell interactions as determinants of the vascular pathology in septic shock.
Funded at Duke University · NIH-10932132 · Data updated 2026-11-12
This study is looking at how platelets and mast cells work together to cause problems with blood vessels during septic shock, which could help us find better ways to treat patients and improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 22, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $416,624 |
| NIH project number | 5R01GM144606-04 |
| Project ID | NIH-10932132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with septic shock who are experiencing severe vascular complications.
✕Less likely to help
Patients with septic shock who do not exhibit significant vascular pathology may not benefit from this research.
What this research studies
This research investigates the interactions between platelets and mast cells to understand how they contribute to blood vessel issues during septic shock. By using advanced imaging techniques, the study aims to identify the cellular mechanisms that lead to severe drops in blood pressure and other vascular complications in patients experiencing septic shock. The researchers will explore how platelets stimulate mast cells, which may play a crucial role in the development of these complications. This work could lead to new insights into the treatment of septic shock and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or prevent vascular complications in patients with septic shock.
How similar studies have gone: Previous research has shown that understanding cellular interactions in vascular pathology can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Abraham, Soman N — Duke University
- Study coordinator: Abraham, Soman N
Related research
Other NIH-funded projects on the same topics.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
-
Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
-
Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
-
Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
-
Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.