Adrenaline versus dopamine for children with fluid-refractory septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized controlled trial enrolling children with fluid-refractory septic shock who are randomized to receive either adrenaline or dopamine. Treatments are compared by monitoring heart rate, Glasgow Coma Scale, capillary refill time, palpable peripheral pulses, urine output, and systolic blood pressure at predefined time points. The trial is conducted at a single pediatric tertiary center in Faisalabad and follows patients through early hemodynamic response. Children with recent cardiopulmonary bypass, major chronic systemic, neuromuscular, or metabolic disorders, or incomplete prior treatment records are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients of both Genders having age range between 1month and 12 years with diagnosis of fluid refractory septic shock as per operational definition.

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Exclusion Criteria:

* Patients with

  1. cardiopumonary Bypass during last 5 days
  2. Chronic Systemic disease like Chronic kidney Disease , cerebral palsy, congenital heart disease
  3. neuromuscular discorder
  4. Metabolic disorders
  5. Those who already had treatment at periphery for hypovolemia without any record of medication or sequential organ failure at presentation

Where it's running

• The Children Hospital and The Institute of Child Health Faisalabad
  Faisalābad, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Hafiz Muhammad Abdullah Dr, MBBS
• Email: mbilal1857@gmail.com
• Phone: 03440846288

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.