Using nerve stimulation to improve blood flow in septic shock patients
Official title: Stellate Ganglion Stimulation in Septic Shock to Improve Hemodynamics and Vasopressor Requirements
Funded at Coridea, LLC · NIH-10921573 · Data updated 2026-11-12
This study is exploring a new way to help people with septic shock by using a gentle technique to stimulate a nerve that can improve blood flow and lessen the need for strong medications, making it safer and more effective for patients.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coridea, LLC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 5, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $274,839 |
| NIH project number | 1R43GM154625-01A1 |
| Project ID | NIH-10921573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing septic shock.
✕Less likely to help
Patients who are not experiencing septic shock or those with contraindications to nerve stimulation may not benefit from this research.
What this research studies
This research investigates a new method to support patients experiencing septic shock, a severe condition that can lead to organ failure and high mortality rates. The approach involves stimulating the left stellate ganglion nerve to enhance blood flow and reduce the need for high doses of vasopressor medications, which can have harmful side effects. By using a minimally invasive technique controlled by a closed-loop system, the stimulation can be adjusted automatically based on the patient's vital signs. This innovative method aims to improve patient outcomes and reduce complications associated with traditional treatments.
Why it matters
Potential benefit: If successful, this research could significantly improve the management of septic shock, leading to better survival rates and fewer side effects for patients.
How similar studies have gone: While nerve stimulation for hemodynamic support is a novel approach, similar techniques have shown promise in other conditions, suggesting potential for success in this area.
Where this research is happening
-
Coridea, LLC
New York, United States Active
Researchers
- Principal investigator: Levin, Howard — Coridea, LLC
- Study coordinator: Levin, Howard
Related research
Other NIH-funded projects on the same topics.
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Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
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Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
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Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
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Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.