Using nerve stimulation to improve blood flow in septic shock patients
Stellate Ganglion Stimulation in Septic Shock to Improve Hemodynamics and Vasopressor Requirements
This study is exploring a new way to help people with septic shock by using a gentle technique to stimulate a nerve that can improve blood flow and lessen the need for strong medications, making it safer and more effective for patients.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coridea, LLC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10921573 on NIH RePORTER |
What this research studies
This research investigates a new method to support patients experiencing septic shock, a severe condition that can lead to organ failure and high mortality rates. The approach involves stimulating the left stellate ganglion nerve to enhance blood flow and reduce the need for high doses of vasopressor medications, which can have harmful side effects. By using a minimally invasive technique controlled by a closed-loop system, the stimulation can be adjusted automatically based on the patient's vital signs. This innovative method aims to improve patient outcomes and reduce complications associated with traditional treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing septic shock.
Not a fit: Patients who are not experiencing septic shock or those with contraindications to nerve stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the management of septic shock, leading to better survival rates and fewer side effects for patients.
How similar studies have performed: While nerve stimulation for hemodynamic support is a novel approach, similar techniques have shown promise in other conditions, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Coridea, LLC — New York, United States (Active)
Researchers
- Principal investigator: Levin, Howard — Coridea, LLC
- Study coordinator: Levin, Howard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.