Using Xanthohumol to help treat septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of Xanthohumol as an adjuvant treatment for patients experiencing septic shock, a severe condition characterized by an overwhelming inflammatory response to infections. The study focuses on patients in the early acute phase of septic shock who require mechanical ventilation due to respiratory insufficiency. By targeting the inflammatory response and cytokine release associated with septic shock, the trial aims to improve organ function and patient outcomes. Participants will be closely monitored in an intensive care unit setting to assess the effectiveness of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* a septic shock in the early, acute phase,
* respiratory insufficiency required mechanical ventilation with PaO2/FiO2 \< 150,
* bacterial infection,
* procalcitonin higher than 5 ng/mL and interleukin 6 higher than 100 pg/mL,
* no allergy to hops or their derivatives,
* hemodynamic instability requiring vasopressor infusions

Exclusion Criteria:

* lack of agreement
* septic shock treated for more than 1 day,
* history of severe chronic cardiac, pulmonary and/or liver diseases

Where it's running

• Intensive Care Unit, University Hospital No 4,
  Lublin, Lublin Voivodeship, Poland Recruiting

Study contacts

• Principal investigator: Wlodzimierz Plotek — Medical University of Lublin, Poland
• Study coordinator: Wojciech Dabrowski, Prof
• Email: wojciech.dabrowski@umlub.pl
• Phone: +48604241040

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using higher PEEP with mask noninvasive ventilation for people with pneumonia or ARDS

  This trial will test whether giving higher PEEP through a mask during noninvasive ventilation helps adults with pneumonia or ARDS avoid intubation and improve oxygenation.

  Recruiting Chongqing Medical University · Chongqing · NCT07298889

• Monitoring blood flow and response to fluids in patients on ECMO

  This study is testing different ways to monitor blood flow and heart function in adults receiving VA ECMO treatment to see which methods work best for their care.

  Recruiting Medical University of Vienna · Vienna · NCT06593756

• Testing monitoring methods for patients on ECMO support

  This study is testing different ways to monitor heart function and fluid levels in patients on ECMO support for severe breathing problems to see which methods work best.

  Recruiting Medical University of Vienna · Vienna · NCT06593717

• Understanding risk factors and biomarkers in ARDS, sepsis, and pneumonia

  This study is trying to find out what causes acute respiratory distress syndrome, sepsis, and pneumonia by collecting health information and samples from hospitalized adults to help improve treatment for these conditions.

  Recruiting at 20 sites Vanderbilt University Medical Center · Fresno, California and 19 other locations · NCT06521502

• Respiratory Physiotherapy in Critically Ill Pneumonia Patients

  This study tests whether a structured breathing and chest therapy program can change inflammatory biomarkers in adults with pneumonia in the ICU compared to usual care.

  Recruiting Hospital H+ Queretaro · Querétaro · NCT07909616

• Adjunctive Fludrocortisone in Septic Shock on Hydrocortisone

  In septic shock, this trial tests whether adding fludrocortisone (50 mcg or 100 mcg daily) to hydrocortisone improves survival and recovery compared with placebo.

  Recruiting at 2 sites Phase 3 The George Institute · Penrith, New South Wales and 7 other locations · NCT07898462

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.