Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
Official title: Percutaneous Stellate Ganglion Stimulation in Septic Shock to Improve Hemodynamics and Vasopressor Requirements During Transport
Funded at Coridea, LLC · NIH-11349290 · Data updated 2026-11-12
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coridea, LLC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2026 |
| Project end | August 14, 2027 |
| Funding year | 2026 |
| Award (this year) | $293,759 |
| NIH project number | 1R43HL186093-01 |
| Project ID | NIH-11349290 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with septic shock who require vasopressors and are being treated in hospital settings.
✕Less likely to help
Patients without septic shock or those not needing vasopressors may not benefit from this approach.
What this research studies
This project explores a new way to support the circulation of people with septic shock using a nerve-stimulating approach. By delivering targeted stimulation to the left stellate ganglion, the system aims to raise arterial pressure and reduce the need for high-dose vasopressors. The researchers will use a portable stimulator to deliver on-demand therapy and measure changes in blood pressure and vasopressor requirements. The team has shown in animal studies that this approach can increase mean arterial pressure quickly and controllably. If successful, this device could offer a safer, more accessible option for patients, including those in rural or underserved areas.
Why it matters
Potential benefit: If successful, patients could experience more stable blood pressure with less reliance on high-dose vasopressors.
How similar studies have gone: Animal studies have shown promising blood pressure effects; human data are not yet available.
Where this research is happening
-
Coridea, LLC
New York, United States Active
Researchers
- Principal investigator: Levin, Howard — Coridea, LLC
- Study coordinator: Levin, Howard
Related research
Other NIH-funded projects on the same topics.
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Using nerve stimulation to improve blood flow in septic shock patients
This study is exploring a new way to help people with septic shock by using a gentle technique to stimulate a nerve that can improve blood flow and lessen the need for strong medications, making it safer and more effective for patients.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
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Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
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Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
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Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
-
Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.