Hydrocortisone plus fludrocortisone for adults with septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized Phase 4 trial enrolls adults aged 18–90 with septic shock diagnosed within 12 hours and assigns them to receive hydrocortisone plus fludrocortisone or standard care. Treatments are given according to a fixed protocol and patients are followed for outcomes including mortality, shock reversal, and adverse events. Key exclusions include recent systemic corticosteroid use, immunosuppression, pregnancy, active gastrointestinal conditions requiring fasting, anticipated death within 90 days, or concurrent trial participation. The trial is conducted at Northern Jiangsu People's Hospital in Yangzhou, Jiangsu, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

(1)18≤Age≤90; (2)Diagnosis of septic shock within 12 h.

Exclusion Criteria:

Patients meeting any of the following conditions will be excluded:

1. Systemic corticosteroid therapy within the last 3 months before septic shock;
2. High-dose steroid therapy;
3. Immunosuppression;
4. Pregnant;
5. Known allergy to hydrocortisone or fludrocortisone;
6. Presence of gastrointestinal bleeding, perforation, or other conditions requiring fasting;
7. Anticipated death from a preexisting disease within 90 days after randomization (as determined by the enrolling physician);
8. Refusal of the attending staff or patient family;
9. Current participation in another clinical trial.

Where it's running

• Northern Jiangsu People's Hospital
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Qingquan Lyu, Master — Northern Jiangsu People's Hospital
• Study coordinator: Qingquan Lyu, Master
• Email: bonhomie2014@163.com
• Phone: 0086-18051063899

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Adjunctive Fludrocortisone in Septic Shock on Hydrocortisone

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• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

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• Personalized Fluid Resuscitation in the Emergency Department

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• Discordance between capillary refill time and oxygen use in septic shock

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• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.