Discordance between capillary refill time and oxygen use in septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center observational cohort study of about 100 adults with septic shock. It compares capillary refill time (CRT) with oxygen extraction ratio (O2ER) at hour 6 of resuscitation to identify a discordant perfusion phenotype. The study aims to describe how common this discordance is and whether it associates with 28-day mortality, as well as to explore related clinical outcomes and validate a proposed O2ER threshold. Data will be collected on perfusion markers, organ support, length of stay, and mortality, with adjustments for baseline severity. Eligibility requires age 18+, septic shock per SSC 2026 guidelines, and presence of both central venous and arterial lines.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of septic shock according to the Surviving Sepsis Campaign (SSC) 2026 guideline
* Presence of both a central venous catheter and an arterial line

Exclusion Criteria:

* Active bleeding
* Ongoing extracorporeal membrane oxygenation (ECMO)
* Raynaud phenomenon or significant peripheral vascular disease that makes capillary refill time measurement unreliable (e.g., critical ischemia, amputation, digital ulcer/necrosis, or inability to measure on the right index finger)
* Death within the first 6 hours
* Inability to obtain hour-6 CRT or blood gas (phenotyping not possible)

Where it's running

• Basaksehir Cam and Sakura City Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Tugba Yesilyurt Dogu, Intensive Medicine Care Fellow
• Email: tugbaayesilyurt@gmail.com
• Phone: +9005535150847

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.