Investigating a new therapy for septic shock using a drug called Dichloroacetate.
Official title: Metabolism and Mitochondrial Energetics Therapy for Septic Shock
Funded at Medosome Biotec, LLC · NIH-11004009 · Data updated 2026-11-12
This study is looking at how a drug called Dichloroacetate (DCA) might help immune cells work better during severe sepsis, a serious condition, by testing it in pigs to see if it’s safe and effective for future use in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medosome Biotec, LLC NIH-funded |
| Lab location | 1 site (Alachua, UNITED STATES) |
| Project start | September 12, 2024 |
| Project end | September 11, 2025 |
| Funding year | 2024 |
| Award (this year) | $350,000 |
| NIH project number | 1R42GM151928-01A1 |
| Project ID | NIH-11004009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing septic shock, particularly those who are critically ill and may benefit from enhanced immune function.
✕Less likely to help
Patients who are not experiencing septic shock or those with contraindications to DCA may not receive any benefit from this research.
What this research studies
This research focuses on how metabolic changes in immune cells affect their function during severe sepsis, a life-threatening condition. The team is exploring the use of Dichloroacetate (DCA), a drug that may help restore energy production in these cells, potentially improving their ability to fight infection. The research involves testing different doses of DCA in pigs, which serve as a model for human sepsis, to assess its safety and effectiveness. The ultimate goal is to gather enough data to support the development of DCA as a treatment for septic shock in humans.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that improves recovery and survival rates for patients suffering from septic shock.
How similar studies have gone: While the use of DCA in this context is novel, previous studies have indicated that metabolic therapies can be beneficial in treating sepsis, suggesting potential for success.
Where this research is happening
-
Medosome Biotec, LLC
Alachua, United States Active
Researchers
- Principal investigator: Alam, Hasan B — Medosome Biotec, LLC
- Study coordinator: Alam, Hasan B
Related research
Other NIH-funded projects on the same topics.
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Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
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Personalized vasopressor therapy for septic shock
A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.
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Angiotensin-based treatment strategy in septic shock
A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.
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Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.
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Macrophage metabolism and septic shock in humans
A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.
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Blood transfusions and organ failure in children with septic shock
This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.