Investigating a new therapy for septic shock using a drug called Dichloroacetate.
Metabolism and Mitochondrial Energetics Therapy for Septic Shock
['FUNDING_OTHER'] · MEDOSOME BIOTEC, LLC · NIH-11004009
This study is looking at how a drug called Dichloroacetate (DCA) might help immune cells work better during severe sepsis, a serious condition, by testing it in pigs to see if it’s safe and effective for future use in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDOSOME BIOTEC, LLC (nih funded) |
| Locations | 1 site (Alachua, UNITED STATES) |
| Trial ID | NIH-11004009 on ClinicalTrials.gov |
What this research studies
This research focuses on how metabolic changes in immune cells affect their function during severe sepsis, a life-threatening condition. The team is exploring the use of Dichloroacetate (DCA), a drug that may help restore energy production in these cells, potentially improving their ability to fight infection. The research involves testing different doses of DCA in pigs, which serve as a model for human sepsis, to assess its safety and effectiveness. The ultimate goal is to gather enough data to support the development of DCA as a treatment for septic shock in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing septic shock, particularly those who are critically ill and may benefit from enhanced immune function.
Not a fit: Patients who are not experiencing septic shock or those with contraindications to DCA may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option that improves recovery and survival rates for patients suffering from septic shock.
How similar studies have performed: While the use of DCA in this context is novel, previous studies have indicated that metabolic therapies can be beneficial in treating sepsis, suggesting potential for success.
Where this research is happening
Alachua, UNITED STATES
- MEDOSOME BIOTEC, LLC — Alachua, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALAM, HASAN B — MEDOSOME BIOTEC, LLC
- Study coordinator: ALAM, HASAN B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.