Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
Official title: Pragmatic trial of midodrine as a vasopressor-sparing agent in septic shock
Funded at Mayo Clinic Rochester · NIH-11621217 · Data updated 2026-11-12
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 5, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $789,678 |
| NIH project number | 4R33HL177037-02 |
| Project ID | NIH-11621217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis-associated hypotension who require vasopressor support or are at risk of prolonged IV vasopressor use.
✕Less likely to help
Patients with contraindications to midodrine or those unlikely to benefit from a vasopressor-sparing strategy.
What this research studies
This trial will enroll adults with sepsis and low blood pressure to see if an oral medicine, midodrine, can spare IV vasopressors and reduce ICU time in a real-world setting. It uses a pragmatic, randomized design to compare midodrine to standard care while monitoring safety closely. If successful, it could offer a simpler, less invasive way to support blood pressure in septic patients and potentially lessen ICU burdens. Participation involves standard clinical care with additional monitoring and follow-up as part of the study. The goal is to improve outcomes and comfort for patients during a critical illness episode.
Why it matters
Potential benefit: If effective, midodrine could reduce ICU stays and exposure to invasive procedures for septic patients with hypotension.
How similar studies have gone: Prior trials have shown mixed results; this study aims to clarify effectiveness in a pragmatic, diverse ICU population.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Gajic, Ognjen — Mayo Clinic Rochester
- Study coordinator: Gajic, Ognjen
Related research
Other NIH-funded projects on the same topics.
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Personalized vasopressor therapy for septic shock
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-
Angiotensin-based treatment strategy in septic shock
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-
Percutaneous stellate ganglion stimulation to support blood pressure in septic shock
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-
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This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.
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How immune cell metabolism affects septic shock
This study is looking at how the way immune cells use energy affects the body's reaction to septic shock, which can happen after a severe infection, and it hopes to find new ways to help people with sepsis feel better by reducing harmful inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.