Condition

ARDS clinical trials and research

• 27Clinical trials
• 87NIH research projects
• 18Countries

Newest ARDS clinical trials

All recruiting trials (27)

• Multicenter group study of sepsis and ARDS in China

  This study tests how sepsis and ARDS differ among adults across several Chinese hospitals and builds a biobank to understand why some patients do better or worse.

  Recruiting at 24 sites Shanghai Zhongshan Hospital · Xiamen, Fujian and 23 other locations · NCT07863908

• Blood viscosity in ARDS: a look at how thick the blood is

  This study tests whether blood viscosity is higher in adults with ARDS and whether viscosity relates to their breathing and blood flow issues.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07823296

• TwitchView-guided Atracurium Dose Adjustment in ICU Patients

  This trial tests whether using a TwitchView EMG monitor to guide atracurium dosing in ICU patients reduces the total amount of the drug given without compromising care.

  Recruiting Fu Jen Catholic University Hospital · New Taipei City · NCT07807046

• Fibrinogen-to-Albumin Ratio as a Predictor of ARDS in Traumatic Brain Injury

  This study tests whether the fibrinogen-to-albumin ratio can predict who among adults with traumatic brain injury will develop acute respiratory distress syndrome (ARDS).

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT07664358

• Gastric versus postpyloric feeding for adults with ARDS on prone ventilation

  This trial will test whether feeding through a stomach tube (nasogastric) or a tube placed past the stomach (nasojejunal) works better for adults with moderate to severe ARDS who are on a ventilator and positioned face-down.

  Recruiting Southeast University, China · Nanjing, Jiangsu · NCT07362537

• Using higher PEEP with mask noninvasive ventilation for people with pneumonia or ARDS

  This trial will test whether giving higher PEEP through a mask during noninvasive ventilation helps adults with pneumonia or ARDS avoid intubation and improve oxygenation.

  Recruiting Chongqing Medical University · Chongqing · NCT07298889

• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

  This trial tests whether a personalized lung volume optimization maneuver using PEEP titration can improve heart and lung function in children after cardiopulmonary bypass surgery or in those with severe respiratory failure at risk for ECMO.

  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• Low-flow ECCO2R for ICU patients with respiratory failure: safety and outcomes

  This review looks back at adults in the ICU who received low-flow ECCO2R to see if the treatment was safe and helped people with respiratory failure, including ARDS and severe asthma.

  Recruiting Hong Kong University · Hong Kong · NCT07161271

• How the length of single-lung ventilation affects lung complications after chest surgery

  This project sees if longer single-lung ventilation during thoracic surgery increases postoperative lung complications in adults aged 18–85.

  Recruiting Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Ankara, Ankara · NCT07100860

• Outcomes of VV-ECMO during emergency thoracic surgery

  This project tries to compare outcomes for adults who receive veno-venous ECMO during or after emergency chest surgery with patients who receive VV-ECMO for medical respiratory failure.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07016685

• Using a special bed to reduce pressure injuries in critically ill patients

  This study is testing if a special bed can help prevent pressure injuries in critically ill adults and elderly patients on ventilators better than regular repositioning methods.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06819943

• Innovative therapies for Acute Respiratory Distress Syndrome

  This study is testing new treatments for adults in the hospital with Acute Respiratory Distress Syndrome to see if they can improve breathing and overall recovery compared to a placebo.

  Recruiting at 27 sites Phase 2 PPD Development, LP · Birmingham, Alabama and 40 other locations · NCT06703073

• Evaluating vilobelimab for treating Acute Respiratory Distress Syndrome

  This study is testing if vilobelimab can help hospitalized adults with Acute Respiratory Distress Syndrome feel better and improve their chances of recovery compared to a placebo.

  Recruiting at 28 sites Phase 2 PPD Development, LP · Birmingham, Alabama and 40 other locations · NCT06701682

• Evaluating a new treatment for Acute Respiratory Distress Syndrome

  This study is testing a new treatment called paridiprubart to see if it can help hospitalized adults with Acute Respiratory Distress Syndrome breathe better and improve their chances of recovery.

  Recruiting at 28 sites Phase 2 PPD Development, LP · Birmingham, Alabama and 40 other locations · NCT06701669

• Evaluating Bevacizumab for Acute Respiratory Distress Syndrome

  This study is testing whether a medication called bevacizumab can help hospitalized adults with Acute Respiratory Distress Syndrome breathe better and improve their chances of recovery.

  Recruiting at 28 sites Phase 2 PPD Development, LP · Birmingham, Alabama and 40 other locations · NCT06701656

• Comparing lateral and prone positioning in ARDS patients

  This study is testing if changing the position of patients with severe lung issues can help them breathe better and get more oxygen.

  Recruiting at 2 sites Centre Hospitalier de Bastia · Bastia, France and 1 other locations · NCT06647784

• Monitoring blood flow and response to fluids in patients on ECMO

  This study is testing different ways to monitor blood flow and heart function in adults receiving VA ECMO treatment to see which methods work best for their care.

  Recruiting Medical University of Vienna · Vienna · NCT06593756

• Testing monitoring methods for patients on ECMO support

  This study is testing different ways to monitor heart function and fluid levels in patients on ECMO support for severe breathing problems to see which methods work best.

  Recruiting Medical University of Vienna · Vienna · NCT06593717

• Understanding risk factors and biomarkers in ARDS, sepsis, and pneumonia

  This study is trying to find out what causes acute respiratory distress syndrome, sepsis, and pneumonia by collecting health information and samples from hospitalized adults to help improve treatment for these conditions.

  Recruiting at 20 sites Vanderbilt University Medical Center · Fresno, California and 19 other locations · NCT06521502

• Using Xanthohumol to help treat septic shock

  This study is testing if a natural compound called Xanthohumol can help improve recovery for patients with septic shock who need breathing support.

  Recruiting Phase 2 Medical University of Lublin · Lublin, Lublin Voivodeship · NCT06225258

• Using HA380 blood filter in critically ill patients needing extracorporeal support

  This study is testing whether a new blood filter can help critically ill patients on dialysis or ECMO recover faster by reducing inflammation and improving their overall care.

  Recruiting University Hospitals, Leicester · Leicester, Leicestershire · NCT06179771

• Finding early biological signs of severe illness in ICU patients

  The study will collect blood, lung, and rectal samples from adults newly admitted to the ICU to see if early biological signs can help diagnose and personalize care for sepsis, ARDS, or other critical illnesses.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05591924

• How PEEP changes ventilation–perfusion matching in two types of ARDS lungs

  This trial will test whether increasing or decreasing PEEP changes ventilation–perfusion matching in adults with moderate-to-severe ARDS who are sedated and on a ventilator.

  Recruiting University Hospital, Angers · Angers, Maine et Loire · NCT05578742

• Using inflatable air bags to improve lung function in ARDS patients in prone position

  This study tests if using inflatable air bags can help improve lung function in patients with Acute Respiratory Distress Syndrome (ARDS) who are lying on their stomachs.

  Recruiting Phase 2 Centre Hospitalier Universitaire, Amiens · Amiens · NCT05515484

• Treatment for Acute Respiratory Distress Syndrome using Extracellular Vesicles

  This study is testing a new treatment called ExoFlo to see if it can help hospitalized patients with moderate-to-severe Acute Respiratory Distress Syndrome breathe better and improve their overall health.

  Recruiting at 31 sites Phase 3 Direct Biologics, LLC · Phoenix, Arizona and 31 other locations · NCT05354141

• Using a decision support tool to improve ventilation in children with ARDS

  This study is trying out a new tool to help doctors manage breathing machines better for kids with serious lung problems to see if it can improve their recovery.

  Recruiting at 6 sites Children's Hospital Los Angeles · Chicago, Illinois and 7 other locations · NCT04068012

• Optimizing Ventilation for Patients with Acute Respiratory Distress Syndrome

  This study tests a new way of using ventilators to see if it can help patients with acute respiratory distress syndrome, including those with COVID-19, live longer and breathe better.

  Recruiting at 33 sites Unity Health Toronto · New York, New York and 32 other locations · NCT03963622

NIH-funded research (newest 40 of 87)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Coordinating ARDS, Pneumonia, and Sepsis research to improve care

  A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11595454

• Lipid-gene Profiles in Septic ARDS

  A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11575353

• Improving blood vessel repair after pediatric ARDS

  Aims to better repair the lungs of children who have ARDS by delivering targeted therapy to lung blood vessels using tiny nanoparticles.

  NIH research University of Arizona · Tucson, United States · NIH-11444432

• NOX4 links to ARDS risk and progression

  Aims to understand how NOX4-driven cell damage may make some adults with ARDS worse off and how this could lead to earlier, targeted care.

  NIH research Marquette University · Milwaukee, United States · NIH-11444021

• Leading causes of death in alcoholic ARDS patients using clinical data

  This project uses big clinical data and AI to find the main factors that cause death in adults with ARDS who have alcohol use issues, aiming to improve understanding and care.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11442761

• Targeting aging-related blood vessel injury to prevent ARDS in older lungs

  Aims to find ways to protect lung blood vessels in older adults to prevent dangerous lung swelling (ARDS).

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11431171

• Innovative immune therapy with antibiotics to treat deadly inflammation in sepsis and ARDS in older adults

  A new approach combines an antibiotic strategy with a special immune-based treatment to help older patients who have sepsis or ARDS from severe bacterial infection.

  NIH research Bioprovar Corporation · Houston, United States · NIH-11417998

• Role of endothelial NAMPT in ARDS: a target to reduce lung inflammation

  Researchers are studying how a molecule called NAMPT released by blood vessel cells contributes to lung inflammation in ARDS and how blocking its signals might help patients.

  NIH research University of Florida · Gainesville, United States · NIH-11417289

• Pre-Clinical Models of ARDS/VILI in Rats and Pigs

  A large animal and rat project to understand how lung injury develops in ARDS and ventilation-related damage, with work aimed at developing better therapies and translating findings to patients.

  NIH research University of Florida · Gainesville, United States · NIH-11417279

• Cytoskeletal control of lung blood vessel biology in ARDS

  A program at a major university is exploring how the cell skeleton in lung blood vessels drives ARDS, with a focus on how leakage and inflammation occur and how this might lead to better therapies.

  NIH research University of Florida · Gainesville, United States · NIH-11417270

• Resilience endotypes and early ARDS detection using biomarkers and AI

  A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.

  NIH research Duke University · Durham, United States · NIH-11416345

• Understanding how the lung’s tiny blood vessels fail in ARDS to guide new therapies

  A research project at Vanderbilt will look for new targets in ARDS by studying lung tissue and gene activity to understand why the alveolar barrier breaks down.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11411197

• Lung-targeted sLNP-delivered CMT-3 for sepsis-related ARDS

  A new lung-targeted therapy using a sulfonium lipid nanoparticle to deliver CMT-3 therapy for adults with sepsis-associated ARDS.

  NIH research Cmtx Biotech, INC. · Kings Park, United States · NIH-11406986

• Role of oxygen-sensing enzymes in protecting lungs during ARDS

  A study in people is not directly involved; the grant tests how specific enzymes in the lungs control inflammation during ARDS using animal models and lab studies to better understand potential treatments for patients.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11406237

• Targeted mRNA therapies to treat ARDS

  A scientist is developing a lung-targeted nanoparticle system to deliver therapeutic mRNA directly to lung cells to help people with ARDS.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11397786

• Cell competition in lung fibrosis and ARDS

  A Mayo Clinic team is studying how lung cells compete and repair after injury in people with severe lung diseases like IPF, ARDS, and after viral infections, to find ways to improve recovery.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11392294

• Alveolar surface protection in women with ARDS

  This grant tests how female biology affects lung lining protection in severe lung failure (ARDS) to guide more targeted therapies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11387458

• TREK-1 potassium channels as a new way to help adults with ARDS

  Researchers are studying a specific lung channel called TREK-1 to see if boosting or preserving it can improve outcomes for adults with ARDS.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11385390

• A new immune-blocking therapy plus antibiotics for severe sepsis and ARDS in older adults

  This project is trying a treatment that restores a natural TREM1 blocker together with antibiotics to help older adults with life-threatening bacterial sepsis or ARDS.

  NIH research Bioprovar Corporation · Houston, United States · NIH-11370765

• TRMT1 and tRNA methylation in acute lung injury and ARDS

  Aims to understand how a RNA-modifying enzyme called TRMT1 affects lung injury and ARDS to help develop new treatments for patients in ICU.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11365169

• Pilot test of a power-guided ventilation strategy for adults on VV-ECMO with severe ARDS

  A small, early-phase study will test whether using a specific “mechanical power” target for ventilation in adults on VV-ECMO with severe ARDS is practical and safe for a future larger trial.

  NIH research University of Virginia · Charlottesville, United States · NIH-11354675

• Understanding muscle wasting in ARDS and how IL-6 and immune cells drive it

  A doctor-scientist-led project will explore whether IL-6 and immune cells called monocytes and macrophages cause early muscle weakness in ARDS, with the goal of finding new ways to protect muscles.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11351491

• mRNA-LNPs to treat ARDS in adults

  A patient-facing program exploring whether tiny, targeted mRNA-delivery particles can reduce lung injury and improve outcomes for adults with ARDS.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11348201

• Alveolar macrophage development in ARDS

  Researchers are studying how lung macrophage cells grow and change during acute respiratory distress syndrome to identify new ways to help patients.

  NIH research University of Washington · Seattle, United States · NIH-11348147

• Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold

  A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11325875

• Coordination and data sharing for ARDS, pneumonia, and sepsis research

  A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11325818

• Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing

  A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11321604

• Personalized care for severe lung failure (ARDS) and sepsis

  This project uses blood markers and routine clinical information to match treatments to people with ARDS or sepsis so each person gets the care most likely to help them.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11310714

• Neutrophils help heal the lung's blood vessels after sepsis-related injury

  Researchers are studying how a specific white blood cell (neutrophil) helps repair lung blood vessels in severe lung injury from sepsis or ARDS, which could lead to new treatments.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11295761

• Understanding why some people with sepsis develop ARDS after ozone exposure

  A study to learn why certain patients with sepsis develop acute lung injury and ARDS after exposure to air pollutants like ozone.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11274655

• New lung blood-vessel stem cells that help repair lungs after ARDS

  The project focuses on a rare lung blood-vessel cell that helps rebuild the lung lining after severe infection-related breathing failure in adults.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11251790

• Different neutrophils in severe COVID-19 lung failure

  This work looks at how different neutrophils cause severe COVID-19 lung failure to help guide better treatments.

  NIH research University of Louisville · Louisville, United States · NIH-11247911

• Understanding how lipid and gene profiles affect septic ARDS

  This study is looking at how certain fats and genes in the body affect patients with septic acute respiratory distress syndrome (ARDS) to understand why some people do worse than others, with the hope of finding better, personalized treatments for them.

  NIH research University of Florida · Gainesville, United States · NIH-11229094

• How aging makes ARDS worse by changing Nox4 activity in lung blood‑vessel barriers

  This work looks at whether age-related rises in a protein called Nox4 make lung blood vessels more leaky in older people with ARDS.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11212813

• How integrin beta4 and kindlin-2 affect lung blood vessel leakiness in ARDS

  Researchers are looking at whether two proteins that help lung blood vessel cells stick together — integrin beta4 and kindlin-2 — influence dangerous fluid leakage in people with ARDS.

  NIH research University of Florida · Gainesville, United States · NIH-11193839

• How a blood protein (eNAMPT) and immune signaling harm blood vessels in severe lung failure (ARDS)

  Looks at whether blocking a blood protein called eNAMPT can reduce blood-vessel inflammation and leakage in people with severe lung failure (ARDS).

  NIH research University of Florida · Gainesville, United States · NIH-11193838

• Animal models for severe lung failure (ARDS) and ventilator-related lung damage

  Using rat and pig models to find ways to protect and repair lungs for people with severe breathing failure (ARDS) and to reduce harm from mechanical ventilation.

  NIH research University of Florida · Gainesville, United States · NIH-11193828

• Lung blood-vessel cell structure and ARDS

  This project looks at how the internal skeleton of lung blood-vessel cells makes vessels leak in adults with ARDS and aims to find targets for new treatments.

  NIH research University of Florida · Gainesville, United States · NIH-11193823

• Blood type A and severe lung failure after sepsis

  Researchers are looking at whether having blood type A helps explain why some adults with sepsis develop life-threatening lung failure called ARDS.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11176940

• Using B cells to improve recovery from acute respiratory distress syndrome (ARDS)

  This study is looking at how special immune cells called B cells might help people recovering from acute respiratory distress syndrome (ARDS) by reducing inflammation and helping the lungs and brain heal.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11175768

Related topics

Quick answers

How many ARDS clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (8 trials), France (6 trials), China (3 trials), Canada (3 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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