Evaluating blood protein levels in children with sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the levels of O-GlcNAcylation in blood proteins among children, particularly focusing on those with suspected or diagnosed sepsis. The research builds on previous animal studies that indicated potential benefits of stimulating O-GlcNAcylation in improving cardiac function and survival during septic shock. By examining both healthy children and those with sepsis, the study seeks to understand the role of this modification in pediatric septic conditions. The findings could provide insights into tailored therapeutic approaches for managing sepsis in children.

Why it matters

Who can join: the full rules

1. Healthy group

   Inclusion Criteria :
   * Age from 0 to 17 years at the time of sampling (including premature infants)
   * Children coming to hospital for a blood sample to be taken as part of a pre-operative check-up, an allergy check-up or a check-up as part of a pathology other than sepsis.
   * Premature infants benefiting from a blood sample as part of their monitoring and management of prematurity
   * Collection of umbilical cord blood
   * Signed consent

   Exclusion Criteria :
   * Children with an infection
   * Children with fever
   * Children with an immune deficiency
   * Children with autoimmune disease
   * Children with metabolic disease
   * Children with haematological diseases
   * Children with a genetic disease
   * Unsigned consent
   * Refusal by parents or child
2. Septic group

Inclusion Criteria :

* Age from 0 to 17 years at the time of sampling (including preterm infants)
* Children with suspected sepsis or diagnosed sepsis according to the 2016 definition
* Premature infants having blood drawn for suspected or diagnosed sepsis
* All responsible bacteria, viruses or fungi
* Signed bio-collection consent

Exclusion Criteria :

* Children with an immune deficiency
* Children with autoimmune disease
* Children with a metabolic disease
* Children with haematological diseases
* Children with a genetic disease
* Unsigned bio-collection consent
* Refusal by parents or child

Where it's running

• Nantes University Hospital
  Nantes, France Recruiting

Study contacts

• Study coordinator: Manon Denis, MD
• Email: manon.denis-med@chu-nantes.fr
• Phone: +33 2 40 08 34 83

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.