Condition

Shock clinical trials and research

• 28Clinical trials
• 83NIH research projects
• 14Countries

Newest Shock clinical trials

All recruiting trials (28)

• Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

  This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT07802379

• Argos system to track cardiac output changes in critically ill patients

  This study tests whether the Argos monitor can reliably track how cardiac output changes after fluid administration or norepinephrine adjustments in critically ill adults already monitored with transpulmonary thermodilution.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT07724262

• Pulse palpation vs arterial blood pressure in circulatory shock

  This study tests how well feeling for a pulse at typical sites matches the actual arterial blood pressure in adults with circulatory shock or risk of failure.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT07609095

• Femoral vein-to-artery diameter ratio to predict fluid responsiveness

  This project will test whether a bedside ultrasound measurement of the femoral vein-to-artery diameter ratio can tell if mechanically ventilated ICU patients with acute circulatory failure or shock will increase their cardiac output after a 500 mL fluid bolus.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT07546656

• Right ventricular–arterial coupling during fluid loading in ICU patients

  This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.

  Recruiting CHU de Reims · Reims · NCT07537621

• Looking at tiny particles in cord blood of babies born before 28 weeks

  The team will test whether extracellular vesicles in umbilical cord blood can help predict serious complications in babies born before 28 weeks of pregnancy.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07273643

• Using the blood protein vasorin to distinguish septic shock from other shocks

  This project will test whether measuring vasorin in blood can tell adults in the ICU with septic shock apart from those with non-septic shock.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07203833

• Digital out-of-hospital care for people with early cardiogenic shock

  This trial tests whether the HeartMed-HF digital out-of-hospital management program can reduce one-year deaths and unplanned hospital readmissions in adults with early cardiogenic shock.

  Recruiting Renmin Hospital of Wuhan University · Wuhan, Hubei · NCT07085221

• Personalized IV fluid care for sepsis in the emergency department

  This study will test whether giving IV fluids based on each adult's heart response helps people with suspected sepsis in the emergency department recover more safely than standard fluid care.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07009665

• Using low-dose vasopressors through peripheral catheters in ICU patients

  This study is testing if giving low-dose vasopressors through regular IVs can safely help critically ill patients in the ICU instead of using more invasive central lines.

  Recruiting Phase 2 Queen's University · Kingston, Ontario · NCT06920173

• Analyzing the effects of fluid bolus treatment in shock patients

  This study is testing how well giving extra fluids helps hospitalized patients in shock by looking at how it affects their heart's ability to pump blood.

  Recruiting Bicetre Hospital · Le Kremlin-Bicêtre · NCT06839404

• Using Angiotensin II to Treat Vasoplegic Shock

  This study is testing if giving angiotensin II can help adults with a specific type of shock improve their blood pressure and reduce the time they spend in the ICU.

  Recruiting at 2 sites University Medical Centre Maribor · Maribor and 1 other locations · NCT06539234

• Examining the Aortic to Radial Pressure Gradient in Shock Conditions

  This study looks at how pressure differences between arteries in patients experiencing shock can help doctors better manage their treatment while they are on medication to support blood pressure.

  Recruiting at 9 sites Hospices Civils de Lyon · Bron and 8 other locations · NCT06460519

• Monitoring transfusions during anesthesia in emergency situations

  This study is looking at how blood transfusions are done during emergency surgeries to help improve future treatment guidelines for patients.

  Recruiting Erasme University Hospital · Anderlecht · NCT06403163

• Evaluating muscle weakness in ICU survivors through exercise testing

  This study is trying to see how problems with blood flow after being in the ICU affect the strength and exercise ability of patients who survived serious illnesses like sepsis and shock.

  Recruiting at 2 sites University of Manitoba · Winnipeg, Manitoba and 1 other locations · NCT06193980

• Monitoring microvascular function in critically ill patients using near-infrared spectroscopy

  This study is trying to see if a special light technology can safely check blood flow in the tiny blood vessels of critically ill patients in the ICU to help understand their health better.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT05985525

• Using umbilical mesenchymal stromal cells to treat septic shock

  This study is testing whether giving umbilical stem cells can help people with septic shock recover better than a placebo.

  Recruiting at 2 sites Phase 2 Ottawa Hospital Research Institute · Ottawa, Ontario and 1 other locations · NCT05969275

• Early treatment with noradrenaline for shock in emergency departments

  This study tests if giving noradrenaline right away helps people in shock feel better and recover faster than just using standard fluids.

  Recruiting at 3 sites Phase 3 Odense University Hospital · Copenhagen and 7 other locations · NCT05931601

• Personalized hemodynamic management for patients in shock

  This study tests if managing blood flow based on hormone levels can help critically ill patients in shock do better and avoid serious kidney problems compared to standard care.

  Recruiting at 2 sites Università Vita-Salute San Raffaele · Dubrava and 2 other locations · NCT05898126

• Evaluating fluid responsiveness in shock patients using tissue Doppler

  This study is testing if measuring heart movement with ultrasound can help doctors tell if patients in shock will benefit from receiving extra fluids.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT05888974

• Individualized blood pressure targets for critically ill patients in shock

  This study is testing if setting personalized blood pressure goals for critically ill patients in shock can help them survive better and avoid serious kidney problems.

  Recruiting University of Newcastle, Australia · Newcastle, New South Wales · NCT05850962

• Effects of higher blood pressure on kidney function in patients with shock

  This study is testing if raising blood pressure helps improve kidney function in patients who are in shock.

  Recruiting at 2 sites University Hospital, Angers · Angers and 1 other locations · NCT05655065

• Comparing techniques for placing central venous catheters

  This study is testing whether using a peripheral intravenous catheter is a better and safer way to place central venous catheters in adults in the emergency department compared to the traditional method.

  Recruiting Phase 4 Montefiore Medical Center · The Bronx, New York · NCT05534971

• Evaluating the use of transesophageal echocardiography in critically-ill patients

  This study tests how using a special heart ultrasound called transesophageal echocardiography can help critically-ill patients in emergency and intensive care settings.

  Recruiting University of Pennsylvania · Chicago, Illinois · NCT04972526

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Understanding how aging cells affect patients with circulatory shock

  This study looks at how aging cells in the blood might affect patients who have gone through circulatory shock, to see if they contribute to complications like infections and heart problems after recovery.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT03559569

• Reducing severe bleeding in trauma patients using expandable foam

  This study tests whether a new foam treatment can help stop severe bleeding in trauma patients with major abdominal injuries before they have surgery.

  Recruiting at 2 sites Arsenal Medical, Inc. · Birmingham, Alabama and 1 other locations · NCT02880163

• Comparing vasoactive drugs for treating shock in ICU patients

  This study tests whether using phenylephrine and vasopressin can help ICU patients in shock feel better compared to the usual treatments of norepinephrine and epinephrine.

  Recruiting Phase 4 University of Chicago · Chicago, Illinois · NCT02118467

NIH-funded research (newest 40 of 83)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock

  A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11621217

• Understanding how small heat shock proteins protect our cells

  A study from the University of Washington explores how tiny chaperone proteins protect eye and other cells from damage, which could help prevent conditions like cataracts and age-related macular degeneration.

  NIH research University of Washington · Seattle, United States · NIH-11609397

• A new approach to freeing HIV from brain cells and reducing brain inflammation

  A patient-focused approach tests a strategy to flush out hidden HIV in the brain and protect brain health by reducing inflammation.

  NIH research American University · Washington, UNITED STATES · NIH-11470903

• Shock patients: better, faster teamwork to find the cause

  A team of clinicians works together to quickly identify the exact cause of a patient’s shock to guide the right treatment.

  NIH research Northwestern University · Chicago, United States · NIH-11414761

• Multi-scale model to improve REBOA use in hemorrhagic shock

  A researcher team is building a computer model to better predict how to use REBOA, a device that can control bleeding in the torso, so patients with severe trauma may survive.

  NIH research Texas Engineering Experiment Station · College Station, United States · NIH-11403777

• Phospholipid nanoparticle fluid to replace blood volume and protect organs in severe bleeding

  A new, bubble-free fluid made of tiny lipid particles is being developed to quickly restore blood volume and protect organs during severe bleeding when real blood isn’t available.

  NIH research Vivacelle Bio, INC. · Fort Wayne, UNITED STATES · NIH-11403577

• Predicting Risk and Treatment Effects in Cardiogenic Shock after Heart Attack

  This grant backs a patient-focused effort to use modern methods to understand how to best use life-saving devices in people who have a heart attack with severe heart pump failure.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11397533

• Heat Shock Factor 1 and cancer: how stress responses shape tumor growth

  This NIH grant looks at how the heat shock response, a cellular stress protection system, is controlled in cancer cells and how it affects tumor growth.

  NIH research Northwestern University · Chicago, United States · NIH-11395414

• Personalized vasopressor therapy for septic shock

  A clinician-scientist at Cleveland Clinic aims to tailor vasopressor treatment for septic shock patients using patient-specific factors.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11394826

• Prescriptive AI for ICU shock care: a patient-facing decision support system

  A hospital-based project aims to help ICU doctors make faster, safer decisions for patients in shock using a smart AI tool.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11393886

• Angiotensin-based treatment strategy in septic shock

  A clinical trial will compare giving Angiotensin II versus standard norepinephrine to support blood pressure in septic shock patients, aiming to improve outcomes.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11393608

• Heat shock protein 90 and alcohol-related liver disease: how macrophages fuel inflammation

  This project looks at how a cellular stress protein, HSP90, affects liver inflammation in people with alcohol-related liver disease by focusing on macrophages.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11374847

• Role of Heat Shock Protein 70 as a Therapeutic Target in T-Cell Lymphomas

  A clinical-relevance study explores a new targeted therapy for difficult-to-treat T-cell lymphomas by focusing on a protein called HSP70.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11364981

• Understanding how trauma and alcohol affect tiny blood vessels

  This grant explores why small blood vessels leak after injury and how alcohol may make it worse, with goals to find new ways to protect patients and improve recovery.

  NIH research University of South Florida · Tampa, United States · NIH-11357562

• Nathan Shock Centers Coordinating Center (NSC3) Renewal

  This NIH grant supports a coordinating center that helps aging research centers work together, share resources, and follow important data policies to advance understanding of aging.

  NIH research American Federation for Aging Research · New York, United States · NIH-11353952

• Role of Proton-Sensing Receptors in Brain Injury with Shock

  Researchers are studying how proton-sensing receptors on brain blood vessels affect outcomes after traumatic brain injury with hemorrhagic shock, to find ways to protect the brain.

  NIH research Washington University · Saint Louis, United States · NIH-11350253

• Percutaneous stellate ganglion stimulation to support blood pressure in septic shock

  A small, portable neuromodulation device would be tested to help people with septic shock maintain blood pressure while doctors adjust medicines.

  NIH research Coridea, LLC · New York, United States · NIH-11349290

• Deep learning to clean CPR artifacts so AEDs can decide quickly

  A deep learning method will clean up ECG signals during CPR to help AEDs make faster, more accurate shock decisions for people with out-of-hospital cardiac arrest.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11345432

• Endothelial control of inflammation after trauma and blood loss

  A doctor-scientist at a major hospital is studying how the blood vessel lining controls inflammation after serious injury and血 loss, with the goal of finding new ways to prevent organ failure.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11334325

• Chemical biology tools to study how Plasmodium heat shock proteins work

  Researchers are developing chemical probes to understand how key malaria proteins (PfHsp90 and PfHsp70-1) function, aiming to find new drug targets for malaria.

  NIH research Duke University · Durham, United States · NIH-11333746

• Bim’s surprising role in heat shock–induced cell death

  A scientist is studying how heat stress kills cells and whether a protein called Bim helps drive that process, which could inform therapies for heat-related illness and cancer.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11331970

• Tissue Perfusion Pressure to Guide Circulatory Shock Care

  A new measure called tissue perfusion pressure (TPP) will be studied to guide treatment of circulatory shock in ICU patients.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11326271

• Macrophage metabolism and septic shock in humans

  A study at Boston Children’s Hospital will explore how immune cells’ metabolism affects severe infection (septic shock) and whether targeting this metabolic pathway could help patients.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11325037

• Stopping inflammation after severe injury and bleeding

  Looking at whether blocking a specific inflammation pathway could help people who suffer severe trauma and major blood loss.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11322225

• Lowering HSF1 to help immune T cells enter metastatic breast tumors

  This work looks at whether lowering a protein called HSF1 can help immune T cells get into metastatic breast tumors for people with metastatic breast cancer.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11310107

• Preventing organ failure after shock in older adults

  Researchers are testing whether blocking digestive enzymes that leak from the gut can prevent organ damage after severe shock in older adults.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11307068

• Drug that targets leukemia stem cells by removing HSF1

  This project aims to use a new small molecule that removes a protein called HSF1 to try to kill leukemia stem cells in people with acute myeloid leukemia.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11291313

• Blood transfusions and organ failure in children with septic shock

  This project looks at how a child’s circulation, immune status, and the type of red blood cells given affect recovery and organ problems during septic shock in young children.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11264949

• Heat shock factors and how they help leukemia cells survive

  Researchers are exploring whether blocking a protein called HSF1 can make adults with acute myeloid leukemia (AML) respond better to treatment.

  NIH research Augusta University · Augusta, United States · NIH-11251979

• Helping blood vessels work better after major bleeding and severe inflammation

  This research looks at how blood vessels behave after traumatic bleeding or severe inflammation to find ways to prevent dangerous low blood pressure in critically ill patients.

  NIH research University of South Florida · Tampa, United States · NIH-11249160

• Creating a model to improve treatment for severe bleeding after trauma

  This study is working on a new computer model to help doctors better manage severe bleeding after injuries, which could lead to better treatments for patients in emergencies.

  NIH research Texas Engineering Experiment Station · College Station, United States · NIH-11177979

• How heat shock factors help cancer cells manage damaging protein stress

  Researchers are learning how proteins called heat shock factors let cancer cells survive harmful protein buildup so they can find new ways to stop tumor growth.

  NIH research Northwestern University · Chicago, United States · NIH-11176246

• Reducing harmful inflammation after severe trauma and major blood loss

  This project aims to find out if blocking a protein called caspase-4 can lower dangerous inflammation and organ damage in people who suffer severe trauma with heavy bleeding.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11170400

• Investigating how heat shock causes cell death through a protein called Bim

  This study is looking at how a protein called Bim causes cell death when the body gets too hot, which could help us find better ways to treat people who struggle with heat-related illnesses or improve cancer treatments that use heat.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11166355

• How ECMO affects the left side of the heart during severe cardiogenic shock

  This project looks at how veno-arterial ECMO (a heart–lung support machine) changes left-heart function in people with cardiogenic shock.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11142616

• How blood vessel cells control inflammation after trauma and shock

  This study is looking at how the cells in your blood vessels help control inflammation after serious injuries and blood loss, with the goal of finding new ways to reduce harmful inflammation and protect your organs if you ever face such a situation.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11132696

• Understanding how a protein called HSP90 affects alcoholic liver disease

  This work explores how a specific protein, HSP90, influences immune cells in the liver to better understand and treat alcoholic liver disease.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11129841

• Targeting leukemia stem cells to improve treatment outcomes

  This study is testing a new treatment called SISU-102 that aims to help people with acute myeloid leukemia (AML) by targeting and eliminating the stubborn leukemia stem cells that make the disease hard to treat, while still allowing healthy blood cells to grow.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11129207

• Better team communication to find the cause of shock

  This project tries a new team-based communication process to help hospital clinicians agree on what's causing a patient's shock so patients get the right care faster.

  NIH research Northwestern University · Chicago, United States · NIH-11128540

• Targeting a protein called HSP70 in T-cell lymphomas

  This project is developing a new drug to specifically target and treat aggressive T-cell lymphomas, which are types of blood cancer that currently have limited treatment options.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11124687

Related topics

Quick answers

How many Shock clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in France (9 trials), Canada (4 trials), United States (4 trials), Netherlands (2 trials), Turkey (Türkiye) (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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