Using vasopressin as a second vasopressor in adult septic shock patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter observational study of critically ill adults (≥18 years) admitted to ICU with septic shock who receive vasopressin in addition to norepinephrine. Investigators will record the norepinephrine dose at vasopressin initiation and collect daily clinical data during the ICU stay using a pseudonymized REDCap database. The main comparisons focus on timing of vasopressin initiation (defined by norepinephrine dose) and relationships with mortality, renal function, and progression of organ dysfunction. No experimental interventions are assigned — treatments follow local clinical practice and are observed for outcome associations.

Why it matters

Who can join: the full rules

Eligible patients for this study must comply with the following requirements.

* ICU admission with a septic shock diagnosis.
* Age 18 years or above at ICU admission.
* Use of vasopressin as an adjunct of norepinephrine.

For the purposes of this study, septic shock is defined by full compliance with the following criteria.

* Sustained arterial hypotension or serum lactate above 2 mmol/L.
* Adequate but unsuccessful fluid resuscitation.
* Vasopressor usage to maintain a mean arterial pressure above 65 mmHg.
* Probable or proven infectious etiology.

Patients with some of the following conditions will be automatically excluded.

* Pregnancy.
* Ischemic cardiogenic shock.
* Acute intestinal ischemia.
* Readmission to the Intensive Care Unit.

Where it's running

• Consorci Sanitari de Terrassa
  Terrassa, Barcelona, Spain Recruiting
• Hospital Universitario de Getafe
  Getafe, Madrid, Spain Recruiting
• Hospital Universitario La Princesa
  Madrid, Madrid, Spain Recruiting
• Hospital General Universitario Gregorio Marañón
  Madrid, Madrid, Spain Recruiting
• Hospital Universitario Ramón y Cajal
  Madrid, Madrid, Spain Recruiting
• Hospital Universitario Clínico San Carlos
  Madrid, Madrid, Spain Recruiting

Study contacts

• Study coordinator: Jamil Antonio Cedeño Mora
• Email: jamilantonio.cedeno@salud.madrid.org
• Phone: +34 630 03 65 02

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.