Cortisol Levels and Mortality in Septic Shock ICU Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study will measure serum cortisol levels in adults with sepsis or septic shock admitted to the intensive care unit and analyze how these levels and their changes relate to outcomes such as ICU, 28-day, and 90-day mortality. The analysis will also explore associations between cortisol and illness severity scores (SOFA, APACHE) and inflammatory biomarkers. The goal is to understand whether cortisol dynamics can serve as a prognostic marker in critical illness due to infection. No intervention is being tested; observations will inform future approaches to risk stratification. The study is conducted at Ankara Etlik City Hospital with adult ICU patients who have confirmed infection and sepsis or septic shock during their ICU stay.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Admission to the intensive care unit for more than 24 hours
* Presence of a clinically or microbiologically confirmed source of infection
* Diagnosis of sepsis or septic shock during ICU stay

Exclusion Criteria:

* Pregnancy
* Known disorders of the hypothalamic-pituitary-adrenal (HPA) axis
* Known disorders affecting cortisol secretion 4.Long-term systemic glucocorticoid use (≥3 months)

Where it's running

• Ankara Etlik City Hospital
  Ankara, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ilkem S. Ersayin, MD
• Email: ilkemselin@gmail.com
• Phone: +90(543)6459248

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.