How immune cell metabolism affects septic shock
Macrophage immunometabolism controls septic shock
This study is looking at how the way immune cells use energy affects the body's reaction to septic shock, which can happen after a severe infection, and it hopes to find new ways to help people with sepsis feel better by reducing harmful inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11096047 on NIH RePORTER |
What this research studies
This research investigates how the metabolism of immune cells, specifically macrophages, influences the body's response to septic shock, a severe condition following sepsis. The study focuses on the interaction between bacterial components and host-derived signals that trigger inflammation. By understanding these metabolic changes, the researchers aim to identify new therapeutic strategies to mitigate the harmful effects of excessive inflammation during septic shock. Patients may benefit from insights that could lead to improved treatments for sepsis and its complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced sepsis or are at risk of developing septic shock.
Not a fit: Patients who do not have a history of sepsis or are not at risk for septic shock may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the severity of septic shock and improve recovery outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in sepsis, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Zanoni, Ivan — Boston Children's Hospital
- Study coordinator: Zanoni, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.