Using angiotensin II to treat septic shock in the emergency department

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to enroll 20 patients experiencing septic shock who require emergency vasopressor support. Participants will receive an intravenous infusion of angiotensin II for blood pressure support, with their response monitored over a 60-minute period. The primary goal is to assess the feasibility of this treatment approach in the emergency department setting, particularly looking for reductions in norepinephrine dosage and improvements in mean arterial pressure. The study will help determine if early administration of angiotensin II can effectively support blood pressure in these critically ill patients.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Age ≥18; and
2. Requiring norepinephrine at a dose of 0.05-0.25 mcg/kg/min mcg/kg/minute despite adequate fluid resuscitation; and
3. Receiving intravenous antibiotics or clinician's intention to administer antibiotics at the time of enrollment; and
4. Can provide written informed consent (or legally authorized representative).

Exclusion Criteria

1. Acute coronary syndrome;
2. Cardiogenic shock;
3. Patients with a history of mesenteric ischemia;
4. Patients with a history of having an aortic dissection or abdominal aortic aneurysm;
5. Patients with an expected lifespan of \<12 hours;
6. Patients with hemorrhagic shock (e.g., actively receiving transfusion of packed red blood cells);
7. Active administration of two vasoactive agents before enrollment; and
8. Pre-existing thromboembolic disease or inability to tolerate pharmacologic VTE prophylaxis.

Where it's running

• University of Iowa Hospitals and Clinics
  Iowa City, Iowa, United States Recruiting

Study contacts

• Study coordinator: Brett Faine, PharmD
• Email: brett-faine@uiowa.edu
• Phone: +1 319 356 2577

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

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• Personalized Fluid Resuscitation in the Emergency Department

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• Discordance between capillary refill time and oxygen use in septic shock

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• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.