Understanding lung endothelial barrier integrity in sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the dynamics of lung endothelial barrier integrity in patients with sepsis, septic shock, and pneumonia. It aims to classify sepsis patients into molecular endotypes to better understand their prognosis and response to treatment. By utilizing blood transcriptomics and bronchoalveolar lavage protein profiling, the study seeks to identify specific biomarkers associated with poor outcomes in sepsis. The findings could help tailor therapeutic interventions based on individual patient profiles.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age ≥ 18 years
* Consent card signed

Exclusion criteria:

* Consent card not signed
* Pregnancy
* Prisoners
* Elective cardiac surgery patients with an uncomplicated stay.

Where it's running

• Mater Dei hospital, Intensive Therapy Unit
  Msida, Malta Recruiting

Study contacts

• Study coordinator: Brendon P. Scicluna, Ph.D.
• Email: brendon.scicluna@um.edu.mt
• Phone: +35623403869

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.