Analyzing metabolic factors in patients with septic shock
Metabolic Cluster Analysis in Septic Shock Patients Undergoing Hemodynamic Resuscitation. A Multicenter Observational Study
This study looks at how giving fluids to patients with septic shock in the ICU affects their heart and metabolism to help find better treatment methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Corporacion Parc Tauli Academic / other |
| Locations | 1 site (Sabadell, Barcelona) |
| Trial ID | NCT06500156 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with septic shock within the first 24 hours of their ICU admission. Participants will be monitored using a cardiac output estimation system while undergoing a fluid challenge to assess hemodynamic and metabolic parameters. The study aims to gather data on the effects of fluid resuscitation on these patients, particularly in relation to tissue hypoperfusion indicators such as elevated lactate levels. The findings could help improve understanding of optimal resuscitation strategies in critical care settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with septic shock within 24 hours of ICU admission who are selected for a fluid challenge due to suspected tissue hypoperfusion.
Not a fit: Patients under 18 years old, those with uncontrolled hemodynamic instability, or those receiving continuous renal replacement therapies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved resuscitation protocols for septic shock patients, potentially enhancing survival rates.
How similar studies have performed: While similar studies have explored fluid resuscitation in septic shock, this specific approach focusing on metabolic cluster analysis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion (elevated lactate and/or ScvO2 \< 70%). Exclusion Criteria: * Age under 18 years old * Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (\> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids. * Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.
Where this trial is running
Sabadell, Barcelona
- Hospital Universitari Parc Taulí — Sabadell, Barcelona, Spain (Recruiting)
Study contacts
- Study coordinator: Jaume Mesquida, MD
- Email: jaume.mesquida@gmail.com
- Phone: +34937231010
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.