Cytokine removal in critically ill patients with infective endocarditis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of cytokine removal in patients undergoing cardiac surgery for infective endocarditis. It focuses on patients who have developed a persistent immunological dysfunction known as injury-associated immunosuppression, which can lead to increased complications and mortality. The intervention involves the use of CytoSorb® treatment to modulate the immune response and potentially improve patient outcomes. The study aims to assess the efficacy of this treatment in reversing the immunosuppressive state associated with severe infections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects scheduled for routine cardiac surgery for infectious endocarditis (diagnosed according to the predefined "DUKE" criteria) with antibiotic therapy for ≤ 14 days.
* Presence of informed consent
* Age ≥18 yrs.

Exclusion Criteria:

* Previous treatment (last 6 months) with immunologically-active biologicals or specific immunomodulatory drugs (e.g. Rituximab)
* high-dose chronic (i.e. before onset of infectious endocarditis) steroid medication with prednisone equivalent of \>30 mg/d
* Patients on Extracorporeal membrane oxygenation (ECMO), or any other (pre-operative) cardiac assist device
* Moribund patient (life expectancy \<14 days)

Where it's running

• Dept of Intensive Care Medicine
  Bern, Switzerland Recruiting

Study contacts

• Study coordinator: Joerg C Schefold, MD
• Email: joerg.schefold@insel.ch
• Phone: 0041-31-632

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.