Using Epoetin Alfa and Iron Derisomaltose to Treat Anemia in Sepsis Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of epoetin alfa and iron derisomaltose in treating anemia among patients diagnosed with sepsis or septic shock in the intensive care unit. The study aims to address the underlying causes of anemia, which can worsen tissue oxygenation in critically ill patients, rather than relying on blood transfusions that may have adverse effects. By utilizing a randomized controlled design, the trial will assess the safety and efficacy of these treatments in improving hemoglobin levels and overall patient outcomes. The study is particularly focused on patients who develop mixed anemia due to sepsis, combining inflammatory anemia and iron deficiency anemia.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. age ≥18,
2. diagnosed sepsis (Sepsis-3) or septic shock (Septic Shock-3),
3. hemoglobin \<120 g/L in both sexes.

Exclusion criteria:

1. bleeding,
2. decompensated liver disease,
3. inherited microcytic disorders,
4. macrocytosis,
5. contraindications to pharmacological prophylaxis of VTE,
6. pregnancy,
7. allergy to epoetin alfa and/or iron derisomaltose,
8. ferritin concentration \>800 ng/mL,
9. unable to take informed consent.

Where it's running

• Uniwersyteckie Centrum Kliniczne im. prof. K. Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach
  Katowice, Poland Recruiting

Study contacts

• Study coordinator: Piotr F. Czempik, MD, PhD
• Email: pczempik@sum.edu.pl
• Phone: 00487894201

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-invasive hemodynamic guidance for sepsis care on medical wards

  This trial tests whether guiding fluid and vasopressor therapy for sepsis using non-invasive hemodynamic measurements works better than standard care.

  Recruiting at 2 sites Regione del Veneto - AULSS n. 7 Pedemontana · Pisa, Pisa and 1 other locations · NCT07863323

• Personalized Fluid Resuscitation in the Emergency Department

  This pilot test checks if a quick, non-invasive stroke-volume assessment can help ED doctors tailor IV fluids for septic patients with low blood pressure.

  Recruiting Intermountain Health Care, Inc. · Murray, Utah · NCT07779720

• Discordance between capillary refill time and oxygen use in septic shock

  This study tests whether some septic shock patients can have a normal capillary refill time but still lack tissue oxygen use, to see if that mismatch relates to 28-day survival.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07774962

• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

• Cortisol Levels and Mortality in Septic Shock ICU Patients

  This study tests whether cortisol levels can predict death or recovery in adults with sepsis or septic shock in the ICU.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07582926

• oXiris hemofilter use for adults with septic shock and kidney failure

  This study tests whether using the oXiris hemofilter during continuous dialysis helps adults with septic shock and acute kidney injury survive and stabilize faster.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07539883

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.