Using albumin and crystalloid fluids to treat septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of early administration of albumin combined with crystalloid fluids for the treatment of septic shock. The study aims to determine if this approach improves survival rates compared to standard resuscitation methods that do not include albumin. Adult patients suspected of having septic shock will be enrolled directly from the emergency department and monitored for outcomes related to fluid resuscitation. The trial builds on previous findings suggesting that albumin may offer additional benefits in managing sepsis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥ 18 years) who visit an ED directly and are suspected of sepsis with shock
* Shock is defined as hypotension (mean arterial blood pressure (MAP) \< 65 or systolic blood pressure \< 80) and tissue hypoperfusion such as an initial serum lactate level ≥ 4 mmol/dL.

Exclusion Criteria:

* patients who are transferred from another hospital after initial fluid administration
* patients who have set limitations on treatment (e.g. patients with a signed do-not-resuscitate order)
* patients with moribund conditions with life expectancy less than 28 days due to secondary diseases or advanced malignant disease and palliative situations with life expectancy less than 6 months
* patients who have been administered albumin before enrollment
* patients who have known hypersensitivity to albumin
* Clinical conditions, where albumin administration may be unfavorable (e.g. pulmonary edema, congestive heart failure, traumatic brain injury)
* lactation
* patients who do not voluntarily consent to participate in the trial.

Where it's running

• Asan Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Sang-Min Kim, Dr.
• Email: swdarkhorse@gmail.com
• Phone: 82-10-3010-0730

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Personalized Fluid Resuscitation in the Emergency Department

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• Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

  This trial tests whether keeping magnesium levels at the upper end of normal can reduce the amount and duration of norepinephrine needed in adults with septic shock.

  Recruiting Alexandria University · Alexandria, Alexandria Governorate · NCT07716956

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.