Echocardiography-guided intensive care for septic shock in people with cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional protocol enrolls critically ill adults with cirrhosis and sepsis-related hypotension and uses point-of-care transthoracic echocardiography to guide fluid resuscitation and vasoactive therapy rather than relying only on fixed pressure targets. Patients who meet inclusion criteria and consent are managed in the ICU with serial POCUS assessments of cardiac function and volume status to tailor therapy. The protocol excludes patients already on vasopressors, with severe cardiopulmonary disease, active major bleeding, advanced renal failure, post‑transplant status, or poor echocardiographic windows. Outcomes focus on hemodynamic stabilization and clinical complications associated with fluid and vasopressor use in this high‑risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Critically ill patient with cirrhosis of any etiology
2. Sepsis-related Hypotension (MAP \<65mmHg or SBP \<90mmHg)
3. 18-65 yrs of age -

Exclusion Criteria:

1. Already on vasopressors/inotropes
2. Severe pre-existing cardiopulmonary disease like porto-pulmonary hypertension (PPH), known coronary artery disease, congenital or valvular heart disease, prosthetic cardiac valves, dilated or restrictive cardiomyopathy.
3. Poor chest wall window due to left pleural effusion, left pneumothorax, small intercostal spaces that restrict performance of a POCUS.
4. Active bleeding like variceal bleed
5. Cerebrovascular events
6. Chronic renal disease - End Stage Renal Disease (ESRD)/ patient on renal replacement therapy
7. Admission to ICU following liver transplantation, burns, cardiac surgery
8. Previous transjugular intra hepatic portosystemic shunt (TIPS),
9. Hepatocellular carcinoma
10. Pregnant or lactating women
11. Informed consent refused by patient or attendants
12. Active COVID-19 infection

Where it's running

• PGIMER Chandigarh
  Chandigarh, India Recruiting

Study contacts

• Study coordinator: Dr Madhumita Premkumar, DM
• Email: drmadhumitap@gmail.com
• Phone: 7087003409

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.