Targeting upper-normal magnesium to see if norepinephrine needs drop in septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this interventional study, adults with septic shock will receive intravenous magnesium sulfate to maintain serum magnesium at upper-normal levels, alongside standard care. The trial will compare this approach to usual treatment to see if it lowers total norepinephrine use, shortens ICU stay, reduces ventilation time, and impacts mortality. Magnesium levels are checked at baseline and every three days, with adjustments to stay within the target range. Data on clinical and demographic factors will be collected to assess safety and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female adult patients (aged ≥18 years) diagnosed with septic shock.
* Resistant septic shock that requires corticosteroids.

Exclusion Criteria:

* Pregnancy.
* Baseline hypermagnesemia (serum magnesium level \> 2.3 mg/dL).
* Renal impairment with creatinine clearance (CrCl) \< 10 ml/min.
* Mixed shock.

Where it's running

• Alexandria Main University Hospital
  Alexandria, Alexandria Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Asmaa K Elharony, PharmD — Faculty of Pharmacy, Alexandria University.
• Study coordinator: Asmaa K Elharony, PharmD
• Email: asmaa.khamis252@gmail.com
• Phone: +201062593630

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.