Improving blood flow in sepsis patients using vitamins

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of vitamin B6, vitamin B12, and vitamin C on microcirculation and organ dysfunction in patients diagnosed with sepsis. A total of 296 patients will be randomized into different groups, with one group receiving a combination of all three vitamins alongside standard sepsis treatment, while control groups will receive varying combinations of the vitamins. The aim is to determine if this vitamin regimen can enhance survival rates and improve clinical outcomes in septic patients. The study focuses on patients in the ICU with a specific diagnosis of sepsis and a defined severity score.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 and \< 85 years old
2. Admitted to ICU
3. Diagnosis of patients with SEPSIS 3.0 (diagnostic criteria) 4, SOFA score is 2-13 points

5\. Obtain the informed consent of the subject or his family

Exclusion Criteria:

1. Patients have absolute contraindications such as vitamin allergy
2. Patients with a history of gout
3. Death is expected within 24 hours
4. Pregnant women
5. Use hydroprednisone or other equivalent dose hormones \> 200mg/d within 24 hours
6. Without the informed consent of the patient or his/her representative
7. Patients with a history of scleroderma
8. Patients with a history of vasculitis
9. Patients with oral mucosal diseases
10. Patients with severe difficulty in opening their mouth and unable to detect sublingual microcirculation

Where it's running

• Sichuan Provincial People's Hospital
  Chengdu, Sichuan, China Recruiting

Study contacts

• Study coordinator: fan Zeng
• Email: zengfan1985@126.com
• Phone: 17744339835

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.