Condition

Infertility clinical trials and research

• 94Clinical trials
• 40NIH research projects
• 28Countries

Newest Infertility clinical trials

All recruiting trials (94)

• AI-assisted embryo selection on day 5 in IVF for infertility

  This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07844083

• Preserving sperm quality with aging through cryopreservation

  This study tests whether freezing and thawing sperm can help keep younger-like DNA and molecular traits in men as they age.

  Recruiting IVI Murcia · Murcia, Murcia · NCT07814235

• Unstimulated Egg Retrieval with CAPA-IVM and Euploid Embryo Transfer

  This study tests whether eggs can be collected without ovarian stimulation, matured in the lab, and used to create a single euploid embryo for transfer in infertility patients.

  Recruiting CARE Fertility Texas · Bedford, Texas · NCT07801105

• Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis

  In people under 40 with deep infiltrating endometriosis and infertility, the study tests whether two injections of a GnRH agonist before hormone support improve pregnancy outcomes in their first frozen-thawed embryo transfer.

  Recruiting Phase 4 Nanjing University · Nanjing, Jiangsu · NCT07696351

• Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy

  This study tests whether patterns of uterine contractions during hormone-prepared frozen embryo transfer affect pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City · NCT07675213

• Environmental and lifestyle factors linked to ART success in infertility patients

  This study follows 5,000 infertile men and women to see how environmental exposures and lifestyle relate to the success of assisted reproductive technology.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07641387

• How Saline Infusion Sonohysterography Helps Assess Cesarean Scar Defects

  This study tests whether saline infusion sonohysterography can reliably detect cesarean scar defects and guide treatment for people experiencing symptoms after cesarean delivery.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07610668

• Fertility outcomes after antibiotic treatment in women with chronic endometritis

  This study tests whether antibiotic therapy can improve fertility and pregnancy outcomes in women with chronic endometritis diagnosed during infertility workups.

  Recruiting at 2 sites Faculty Hospital Kralovske Vinohrady · Prague and 1 other locations · NCT07603492

• Ultra-rapid blastocyst vitrification for donor oocyte cycles

  This pilot study tests whether ultra-rapid blastocyst vitrification is safe and feasible for donor oocytes compared with the standard method.

  Recruiting Fundacion Dexeus · Barcelona and 1 other locations · NCT07556601

• Safety and efficacy of Corifollitropin Alfa N02 for older women undergoing IVF/ICSI

  This observational study tests whether Corifollitropin alfa N02 injections are safe and effective for women aged 36–40 undergoing IVF/ICSI with COS.

  Recruiting Changchun GeneScience Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT07553728

• Restoring fertility by autografting frozen immature testicular tissue

  This pilot trial will try transplanting a man's own immature testicular tissue, frozen during childhood, back into adult men with azoospermia who want to have children.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT07542626

• Microbiome and metabolome profiles in couples having IVF

  This will test whether partners' microbiome and metabolome profiles are linked to fertilization, pregnancy, and live birth in couples having IVF.

  Recruiting at 3 sites Karolinska Institutet · Malmö and 2 other locations · NCT07532629

• Female Reproductive Health in the Canadian Armed Forces: Understanding Issues from Contraception to Pelvic Floor Dysfunction

  This observational study looks at reproductive health among women in the Canadian Armed Forces to see how contraception, pregnancy outcomes, infertility, pelvic floor issues, and related factors affect service members and veterans.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT07524764

• AI-guided trigger timing to optimize egg retrieval in IVF

  This trial tests whether an AI program can guide monitoring and the ovulation trigger to produce similar or better IVF cycle results than decisions made by doctors.

  Recruiting Fundacion Dexeus · Sabadell, Barcelona and 4 other locations · NCT07515118

• Progesterone support after letrozole-stimulated IUI

  This trial tests whether adding vaginal progesterone after letrozole-stimulated intrauterine insemination helps more people become pregnant.

  Recruiting Phase 4 University of Aarhus · Copenhagen and 3 other locations · NCT07508657

• Pentoxifylline to improve uterine lining and frozen embryo transfer outcomes

  This trial sees if giving pentoxifylline alongside standard estradiol helps women with good-quality day‑5 frozen embryos get a thicker uterine lining and better frozen embryo transfer success.

  Recruiting Phase 3 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07499817

• How anticoagulant medicines affect the uterine lining and pregnancy chances in women with infertility

  This study will see if routine anticoagulant medicines like low-dose aspirin or heparin change endometrial receptivity and improve early pregnancy outcomes in women aged 20–45 with infertility.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07494877

• Aromatherapy to support mental health in women undergoing IVF

  This will test whether inhaling lavender oil twice daily can reduce anxiety, stress, and depression and improve quality of life for women awaiting IVF.

  Recruiting Federal University of Minas Gerais · Belo Horizonte, Minas Gerais · NCT07480668

• Pesticide exposure, cell-free DNA, and gut/genital microbiome signatures in women with endometriosis

  This project will test whether pesticide exposure is linked to oxidative-stress-related changes in circulating cell-free DNA and to differences in the gut and genital microbiomes in women with endometriosis and infertility.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07471373

• Comparing two vaginal progesterone forms for frozen embryo transfer

  This compares whether soft vaginal progesterone capsules are easier to use, better tolerated, and give similar pregnancy results as vaginal progesterone pessaries for women having frozen embryo transfer.

  Recruiting Instituto Valenciano de Infertilidade de Lisboa · Lisbon · NCT07461909

• Standardizing embryo transfer steps for frozen embryo transfers

  This trial tests whether using specialized transfer devices to keep embryos warm and deliver them with precise, controlled motion can increase pregnancy success for people having frozen embryo transfer after IVF/ICSI.

  Recruiting Przychodnia Lekarska nOvum Katarzyna Kozioł, Piotr Lewandowski sp.k. · Warsaw · NCT07396181

• How infertility and fertility treatments affect women's sexual function and behavior

  This project tries to see if infertility and fertility treatments like IVF change sexual desire, satisfaction, or sexual activity in women under 45 seeking fertility care.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07376109

• Outcomes for couples after unsuccessful PGD at the Paris PGD Center

  This project will see what happens next for couples who started PGD at the Paris center but did not have a live birth from that care.

  Recruiting Assistance Publique - Hôpitaux de Paris · Clamart · NCT07371312

• How frozen embryo transfer preparation affects uterine wave activity

  We will test whether preparing for frozen embryo transfer with hormones or using a natural cycle changes uterine contractions in women having FET.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City and 1 other locations · NCT07358468

• Comparing follitropin alfa/lutropin alfa versus hMG for Japanese women with LH and FSH deficiency undergoing assisted reproductive treatment.

  This will test whether a combined follitropin alfa/lutropin alfa injection works as well as hMG for Japanese premenopausal women with LH and FSH deficiency who are undergoing assisted reproductive technology.

  Recruiting at 21 sites Phase 3 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · Akita, Akita and 20 other locations · NCT07340827

• Growth hormone versus DHEA to boost follicle response in IVF for poor ovarian responders

  This trial will test whether adding growth hormone or DHEA helps women with poor ovarian reserve produce more and larger follicles during ICSI.

  Recruiting Phase 2/3 Beni-Suef University · Banī Suwayf, Beni Suweif Governorate · NCT07323329

• Levothyroxine for women with mild (subclinical) hypothyroidism having IVF/ICSI and frozen embryo transfer

  This project will try giving low‑dose levothyroxine to women with subclinical hypothyroidism undergoing IVF/ICSI with frozen embryo transfer to see if it improves pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City, Ho Chi Minh and 1 other locations · NCT07257250

• Semaglutide before IVF to improve embryo quality for overweight and obese women

  This trial tests whether 12 weeks of semaglutide before ovarian stimulation helps overweight and obese women produce more good-quality blastocysts than no pre-treatment.

  Recruiting Phase 4 Fundacion Dexeus · Sabadell, Barcelona and 4 other locations · NCT07242534

• Warmed versus room-temperature contrast during hysterosalpingogram to reduce cramping and false tubal blockage

  This trial will test whether warming the contrast dye used during HSG reduces pain and the chance of a false proximal tubal blockage for women 18–45 having tubal testing for infertility.

  Recruiting Early Phase 1 University of Oklahoma · Oklahoma City, Oklahoma · NCT07226310

• Automated freezing of eggs and embryos

  This study will test whether a new automated system called PRESERVE-CR can freeze eggs and embryos as effectively as manual vitrification by embryologists for people having IVF/ICSI.

  Recruiting Conceivable Life Sciences · Manchester · NCT07197983

• Atosiban for women with prior implantation failure and abnormal uterine contractions

  This trial tests whether giving atosiban around the time of a single blastocyst transfer helps women aged 20–40 with prior implantation failures and abnormal uterine contractions have more live births.

  Recruiting Northwest Women's and Children's Hospital, Xi'an, Shaanxi · Xi'an, Shaanxi · NCT07185230

• Extended vs standard letrozole for ovulation induction in women with PCOS.

  This test will see if taking letrozole for 10 days helps women with PCOS ovulate and get pregnant better than the usual 5-day course.

  Recruiting Embrionare · São Paulo, São Paulo · NCT07159880

• Fixed 3.66 mcg Rekovelle (follitropin delta) for ovarian stimulation before intrauterine insemination

  This test tries a fixed 3.66 mcg dose of Rekovelle (follitropin delta) to stimulate the ovaries of women 18–38 with regular cycles undergoing their first IUI to encourage two follicles and reduce the chance of multiple pregnancy.

  Recruiting at 4 sites Phase 2 Centre Hospitalier Intercommunal Creteil · Bruges and 4 other locations · NCT07153367

• Online health searching and stress during infertility treatment

  This project tests whether frequent online searching about health (cyberchondria) is linked to higher stress and poorer emotional and social well-being in Turkish-speaking women receiving infertility treatments like IUI, IVF, or ICSI.

  Recruiting Acibadem University · Istanbul, Ataşehir · NCT07126769

• IntelliWell: AI imaging to find ultra-rare sperm in testicular tissue

  This will try an AI-assisted imaging platform to find rare sperm in testicular samples from men with non-obstructive azoospermia when standard processing finds no sperm.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07074015

• Tracking outcomes after transferring embryos with non-euploid PGT-A results

  This registry collects pregnancy and child health information from people using IVF who plan to transfer embryos with non-euploid PGT-A results to see what the outcomes are.

  Recruiting Inception Fertility Research Institute, LLC · Houston, Texas · NCT07036536

• Ovarian PRP injections to try to improve embryo quality

  This study tries ovarian platelet-rich plasma (PRP) injections to see if they improve embryo development for people doing IVF.

  Recruiting Generation Next Fertility · New York, New York · NCT07020546

• Using Rekovelle (follitropin delta) with a long GnRH‑agonist protocol for IVF/ICSI

  This study tries individualized dosing of follitropin delta (Rekovelle) based on weight and AMH for women undergoing IVF or ICSI with a long GnRH‑agonist protocol.

  Recruiting at 4 sites University of Luebeck · Düsseldorf, North Rhine-Westphalia and 3 other locations · NCT06995261

• Evaluating a new sperm-wash device for improving intrauterine insemination outcomes in infertile couples

  This study is testing a new sperm-wash device to see if it can help infertile couples have a better chance of getting pregnant through intrauterine insemination.

  Recruiting Chung Shan Medical University · Taichung, Taichung City · NCT06956287

• Intrauterine insemination at 42 hours versus 36 hours after the hCG ovulation trigger

  This study will test whether doing IUI 42 hours instead of 36 hours after the hCG shot leads to more live births for people having intrauterine insemination for infertility.

  Recruiting University Hospital, Toulouse · Bordeaux and 3 other locations · NCT06804538

• Comparing timing of embryo transfer in women with recurrent implantation failure

  This study is testing if timing frozen embryo transfers based on a special test can help women with repeated implantation failures get pregnant more successfully than using the usual timing methods.

  Recruiting The University of Hong Kong · Hong Kong · NCT06762626

• Using liraglutide to improve fertility in obese women with PCOS

  This study is testing if giving liraglutide, along with metformin, can help obese women with PCOS improve their chances of having a baby through IVF by losing weight and getting healthier.

  Recruiting Phase 4 Peking University Third Hospital · Beijing, Beijing Municipality and 2 other locations · NCT06742710

• Using AI to predict uterine lining receptivity during IVF

  This project will try using artificial intelligence to read routine vaginal ultrasound images of the uterine lining to see if it can predict implantation success for people aged 18–40 undergoing IVF with a single blastocyst transfer.

  Recruiting Gottsegen National Cardiovascular Institute · Budapest · NCT06717802

• Impact of Barbed Suture on Uterine Healing After Cesarean Section

  This study tests if using barbed sutures instead of regular sutures during cesarean sections helps pregnant women heal better and reduces complications.

  Recruiting Hospital Clinic of Barcelona · Barcelona · NCT06691750

• Exploring how language affects fertility treatment progress

  This study is testing whether Spanish-speaking patients have a better experience and faster progress in fertility treatments when they communicate with a Spanish-speaking provider instead of using an interpreter.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06636838

• In vitro maturation of human eggs for fertility treatment

  This study is testing a new way to help women with fertility issues by maturing their eggs in the lab with fewer hormones to see if it makes treatment easier and safer.

  Recruiting Colorado Center for Reproductive Medicine · Lone Tree, Colorado · NCT06633120

• Impact of PICSI on embryo quality in infertility treatment

  This study is testing if a special sperm selection method called PICSI can improve the quality of embryos for couples trying to conceive through assisted reproductive technology.

  Recruiting Merrion Fertility Clinic · Dublin, Dublin · NCT06602687

• Using artificial intelligence to improve oocyte and embryo quality assessment in fertility treatments

  This study is testing whether using artificial intelligence can help improve the quality of eggs and embryos in fertility treatments like IVF to boost the chances of pregnancy.

  Recruiting at 4 sites Charles University, Czech Republic · Prague and 3 other locations · NCT06539104

• Non-invasive assessment of embryo development for IVF

  This study is testing if using time-lapse imaging and genetic testing can help choose the best embryos for women undergoing IVF to improve their chances of pregnancy.

  Recruiting at 8 sites Igenomix · Dobl and 7 other locations · NCT06524648

• Mapping the cellular landscape of endometriosis

  This study is trying to understand the differences between healthy tissue and endometriosis by looking at samples from women during their menstrual cycles to see how certain cells and hormones are involved in the condition.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06502548

• Comparing two types of transfer mediums for embryo implantation success

  This study is testing if using a thicker gel called EmbryoGlue® helps more couples have healthy babies compared to a thinner gel during embryo transfers.

  Recruiting Northwest Women's and Children's Hospital, Xi'an, Shaanxi · Xi'an, Shaanxi · NCT06492785

• Comparing Day 5 and Day 6 Embryo Transfers for Pregnancy Rates

  This study is testing whether transferring embryos on day 5 or day 6 after treatment can lead to higher pregnancy rates for people undergoing fertility treatment.

  Recruiting Infertility Treatment Center Dortmund · Dortmund, North Rhine-Westphalia · NCT06447077

• Pulsatile FSH treatment for women with obesity to improve fertility

  This study is testing if a new way of giving hormone treatment can help women with obesity who are having trouble getting pregnant.

  Recruiting Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT06414096

• Is Day 3 vs Day 5-7 Assisted Hatching Helpful in IVF with PGT-A

  This trial tests whether performing assisted hatching at Day 3 or at the blastocyst stage (Day 5-7) helps patients undergoing IVF with PGT-A to improve outcomes, using a within-patient split design.

  Recruiting Reproductive Medicine Associates of New Jersey · Marlton, New Jersey · NCT06377917

• Genetic testing for embryo quality in women aged 37-41

  This study is testing if a genetic test for embryo quality can help women aged 37 to 41 who are trying to get pregnant through fertility treatments have better chances of a successful pregnancy.

  Recruiting Copenhagen University Hospital, Rigshospitalet · København Ø · NCT06358547

• Comparing immediate and postponed embryo transfer for infertility treatment

  This study is testing whether transferring an embryo right after egg retrieval is just as effective as waiting to transfer it later for helping people with infertility have a baby.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT06304792

• Evaluating oocyte competence in egg donors

  This study is testing how certain cell signals in egg donors can help predict which eggs are most likely to be successful for fertility treatments.

  Recruiting Fertiga, Belgium · Barcelona · NCT06280677

• Using antioxidant-rich media to improve embryo quality in IVF

  This study is testing if using a special culture solution with antioxidants can help improve the quality of embryos for people undergoing IVF.

  Recruiting ART Fertility Clinics LLC · Abu Dhabi, Abu Dhabi Emirate · NCT06261671

• Dydrogesterone versus GnRH antagonist for women with low ovarian response using double ovarian stimulation

  This trial will test whether dydrogesterone or a GnRH antagonist better prevents a premature LH surge and improves outcomes and costs for women with poor ovarian response undergoing double ovarian stimulation for IVF.

  Recruiting Phase 2 Bedaya Hospital · Cairo, Cairo Governorate and 1 other locations · NCT06212102

• Collection of biological samples from patients and healthy donors for urological diseases

  This study is collecting blood, urine, and other samples from patients with urological diseases and healthy donors to see if they can find new ways to diagnose and understand these conditions better.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT06187870

• Using hyaluronan-enriched medium to improve embryo transfer outcomes

  This study is testing if using a special gel called EmbryoGlue during frozen embryo transfers can help women with healthy embryos get pregnant more successfully.

  Recruiting ART Fertility Clinics LLC · Abu Dhabi, Abu Dhabi Emirate · NCT06165367

• Comparing sperm selection methods for intrauterine insemination

  This study is testing two different ways to prepare sperm for couples trying to get pregnant through intrauterine insemination to see which method leads to more successful pregnancies.

  Recruiting Universitair Ziekenhuis Brussel · Brussels · NCT06144268

• Comparing generic and reference cetrorelix acetate for ovarian stimulation in IVF

  This study is testing if a generic version of cetrorelix acetate works just as well as the brand-name version for women undergoing IVF treatment.

  Recruiting Northwest Women's and Children's Hospital, Xi'an, Shaanxi · Xi'an, None Selected · NCT06023602

• Comparing two methods for sperm preparation in IVF

  This study is testing which of two sperm preparation methods helps improve the chances of having healthy embryos for couples undergoing IVF.

  Recruiting The University of Hong Kong · Hong Kong, Hong Kong · NCT06023472

• Examining discarded materials from IVF cycles to understand treatment outcomes

  This study is trying to see if analyzing leftover materials from IVF cycles can help predict which treatments will be successful and improve the chances of pregnancy.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06021340

• Comparing two methods for sperm preparation in IVF

  This study is testing whether a new sperm preparation method using a microfluidic chip can help infertile women under 43 have more successful pregnancies through IVF compared to the traditional method.

  Recruiting The University of Hong Kong · Hong Kong, Hong Kong · NCT06005311

• Comparing two methods for processing semen quality in infertility treatment

  This study is testing a new way to process semen to see if it can better preserve sperm quality for men undergoing infertility treatment compared to the traditional method.

  Recruiting The University of Hong Kong · Hong Kong, Hong Kong · NCT05978947

• Comparing two doses of vaginal progesterone for frozen embryo transfers

  This study is testing whether a lower dose of vaginal progesterone can help women achieve successful pregnancies just as well as a higher dose during frozen embryo transfers.

  Recruiting Phase 3 Fundacion Dexeus · Barcelona · NCT05899010

• Comparing two methods for assessing fertility in women

  This study is testing whether a common fertility test using oil-based contrast can help women have more babies compared to a foam-based test.

  Recruiting Amsterdam UMC, location VUmc · Amsterdam · NCT05882188

• Investigating the link between AMH levels and embryo ploidy status

  This study is trying to see if the levels of a hormone called AMH in the ovaries can help predict the quality of embryos created during fertility treatments.

  Recruiting ART Fertility Clinics LLC · Abu Dhabi, Abu Dhabi Emirate · NCT05837325

• Investigating the effects of immune cell treatment on endometrial health for infertility

  This study is testing whether a new immune cell treatment can improve the health of the uterus in women who have unexplained infertility to help them get pregnant.

  Recruiting Nadezhda Women's Health Hospital · Sofia, Sofia · NCT05775211

• Comparing two methods of sperm preparation for intrauterine insemination

  This study is testing which of two sperm preparation methods helps couples trying to get pregnant through intrauterine insemination achieve better pregnancy outcomes.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05693220

• Investigating the risks of anabolic steroid use in fitness communities in Denmark

  This study looks at the long-term health risks of using anabolic steroids among recreational athletes in Denmark to see how it affects their heart, diabetes, reproductive health, and mental well-being.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT05599438

• Measuring free radicals in human sperm related to lifestyle and microbiota

  This study is testing how free radicals in sperm might affect male infertility by looking at their levels in relation to lifestyle and gut bacteria.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT05514223

• Selecting sperm for gender-specific offspring

  This study is testing a new way to choose sperm based on whether it carries an X or Y chromosome to help couples undergoing infertility treatment have a baby of a specific gender.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05500573

• Investigating food intake's impact on fertility treatment outcomes

  This study is trying to see how what people eat affects the success of fertility treatments for couples undergoing assisted reproductive technology.

  Recruiting at 8 sites Aalborg University Hospital · Aalborg and 7 other locations · NCT05454046

• Individual dosing of Follitropin Delta for ovarian stimulation in infertility treatment

  This study is testing if adjusting the dose of a hormone called Follitropin Delta based on a woman's weight and hormone levels can help improve ovarian stimulation for women undergoing IVF or ICSI.

  Recruiting University of Luebeck · Lübeck, Schleswig-Holstein · NCT05173597

• Mannose-binding lectin levels and repeated pregnancy or implantation failure

  This project will test whether low blood levels of mannose-binding lectin are linked to repeated pregnancy loss, repeated failed embryo transfers after IVF/ICSI/FET, or other unexplained infertility in people with three consecutive pregnancy failures.

  Recruiting Aalborg University Hospital · Aarhus · NCT05169541

• Web-based mind-body intervention for women facing infertility

  This study is testing a web-based program that helps women dealing with infertility manage stress and improve their emotional well-being to see if it can also boost their chances of getting pregnant.

  Recruiting Taipei Medical University · Taipei · NCT04829877

• Personalized addition of LH in ovarian stimulation for infertility treatment

  This study is testing if adding a hormone called LH to the usual fertility treatment can help women aged 35 to 40 have better chances of getting pregnant through IVF.

  Recruiting Phase 4 Fundacion Dexeus · Barcelona · NCT04719000

• Evaluating fertility treatments and preservation methods

  This study looks at how well different fertility treatments and preservation methods work for people facing infertility or needing to preserve their fertility due to cancer or other health issues.

  Recruiting Karolinska Institutet · Stockholm · NCT04602962

• Long-term follow-up for patients using preimplantation genetic testing

  This study is trying to learn about the long-term experiences and outcomes of people who have used preimplantation genetic testing during IVF to help improve care in reproductive genetics.

  Recruiting Genomic Prediction Inc. · North Brunswick, New Jersey · NCT04477863

• Investigating outcomes of transferring mosaic embryos in infertility treatment

  This study is trying to see if transferring mosaic embryos, which have both normal and abnormal cells, can help women aged 18-45 who are undergoing IVF have successful pregnancies and live births.

  Recruiting Colorado Center for Reproductive Medicine · Lone Tree, Colorado · NCT04472156

• Using AI to improve IVF and ART outcomes

  This study is testing whether using artificial intelligence can help doctors better predict the success of IVF treatments by analyzing patient data and ultrasound images.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT04255615

• Observational study on women's menstrual health using an app

  This study is trying to learn more about women's menstrual health and related conditions by having women use an app to share their experiences.

  Recruiting Apple Inc. · Boston, Massachusetts · NCT04196595

• Investigating the role of hormones and microbiome in pregnancy during assisted reproduction

  This study is trying to see how hormone levels and the bacteria in the vagina and uterus affect early pregnancy in women undergoing assisted reproduction with frozen embryos.

  Recruiting at 5 sites University of Luebeck · Saarbrücken, Saarland and 4 other locations · NCT03507673

• Fertility preservation for breast cancer patients using tamoxifen or letrozole

  This study is testing whether tamoxifen or letrozole works better with fertility drugs to help women with breast cancer save their eggs before treatment.

  Recruiting Phase 3 University of California, San Francisco · San Francisco, California · NCT03011684

• Complete colorectal deep infiltrating endometriosis surgery before IVF to improve fertility

  This trial tests whether having complete surgery for colorectal deep infiltrating endometriosis before in vitro fertilization (IVF) helps women with endometriosis and infertility get pregnant.

  Recruiting at 5 sites University Hospital, Lille · Clermont-Ferrand and 4 other locations · NCT02948972

• Preserving testicular tissue in boys facing fertility risks

  This study is testing a way to freeze testicular tissue for boys aged 0-17 who might lose their ability to have children due to medical treatments.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02872532

• Treatment to improve fertilization in infertility cases

  This study is testing a new way to help couples struggling with infertility by improving the chances of fertilization and embryo development.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT01944332

• Understanding inherited reproductive disorders

  This study looks at how certain reproductive disorders, like delayed or early puberty, might run in families by testing blood samples and gathering information from people who have these issues.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT01500447

• Using discarded embryos to improve IVF techniques

  This study is testing ways to use leftover embryos from IVF to improve how embryos are handled in the lab, aiming to boost their quality and survival rates for people trying to conceive.

  Recruiting Reproductive Medicine Associates of New Jersey · Basking Ridge, New Jersey · NCT01219335

• Deriving human embryonic stem cell lines from embryos tested for genetic abnormalities

  This study is trying to create new human stem cell lines from embryos that were found to have genetic issues so that researchers can use them to learn more about diseases and develop new treatments.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT00353210

• Creating new human embryonic stem cell lines for clinical use

  This study is trying to create new human embryonic stem cell lines from donated embryos to see if they can be safely used in future treatments for conditions that need regenerative medicine and transplants.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT00353197

NIH-funded research (40)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Molecular clues to endometriosis-related infertility

  This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11595518

• Oral FSH receptor activator drugs to lower infertility treatment costs

  A new oral drug approach aims to improve fertility treatments by using a small molecule that activates the FSH receptor, potentially making infertility care more affordable.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11464481

• Prediction of ART outcomes for male factor infertility using single-molecule chromatin stenciling in sperm

  A new test called sperm Fiber-seq is being developed to better predict how well ART will work for couples dealing with male-factor infertility.

  NIH research Yale University · New Haven, United States · NIH-11456508

• TLR4 blocker for improving fertility in PCOS

  A promising, already-approved drug (disulfiram) will be tested to see if it can reduce inflammation and improve ovulation in women with PCOS.

  NIH research University of California-Irvine · Irvine, United States · NIH-11456298

• Innovative 3D-printed vaginal ring for progesterone delivery to support IVF pregnancies

  A new 3D-printed vaginal ring delivers progesterone over 28 days for IVF patients, aiming to improve pregnancy success with fewer rings and less frequent dosing.

  NIH research Anelleo, INC. · Chapel Hill, United States · NIH-11409203

• Genetics of Male Infertility: Accelerating Discovery and Clinical Impact

  This grant aims to uncover the genetic causes of male infertility (azoospermia) to improve diagnosis and pave the way for personalized treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11400046

• Infertility and long-term health in Hispanic women with Mexican heritage

  A large study will follow Hispanic women with Mexican heritage to understand how infertility relates to cancer, diabetes, and heart-related illnesses over time.

  NIH research University of Arizona · Tucson, United States · NIH-11387558

• Epigenetic test to guide long-term care for men with severe infertility

  A lab test that reads epigenetic signals to guide care for men with severe infertility called non-obstructive azoospermia.

  NIH research Inherent Biosciences, INC. · Salt Lake City, UNITED STATES · NIH-11370929

• Gut soy and male fertility: how the gut microbiome may affect testosterone and sperm health

  This grant explores how soy foods interact with the gut microbiome to influence male reproductive health, especially testosterone levels and sperm quality, in adults.

  NIH research Purdue University · West Lafayette, United States · NIH-11354651

• How IVF benefit designs shape pregnancy outcomes

  This research looks at how employer-provided IVF insurance benefits affect the choices patients make and the health outcomes of mothers and babies.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11345946

• Improving Ovarian Response in Refractory Infertility with Pulsatile FSH

  A study testing pulsatile FSH treatment in women facing obesity-related subfertility to help their ovaries respond better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11339129

• Body clock's role in Chlamydia-linked fallopian tube infertility

  This project looks at whether your body's internal clock affects how Chlamydia infections can damage the fallopian tubes and lead to infertility.

  NIH research Morehouse School of Medicine · Atlanta, United States · NIH-11326267

• Non-invasive menstrual biomarker test for endometriosis in infertility patients

  A non-invasive test using menstrual fluid is being developed to help diagnose endometriosis in people dealing with infertility.

  NIH research Nextgenjane, INC. · Oakland, UNITED STATES · NIH-11321735

• How heat harms sperm chromosome structures linked to male infertility

  This work looks at how warmer-than-normal temperatures change the protein structures that organize chromosomes during sperm production, which could help men with heat-related infertility.

  NIH research Colorado State University · Fort Collins, United States · NIH-11310215

• Understanding how temperature affects male fertility through chromosome structures

  This study looks at how heat affects sperm production in males, using tiny worms to understand why higher temperatures might lead to infertility and possibly increase cancer risk, helping us learn more about male reproductive health.

  NIH research Colorado State University · Fort Collins, United States · NIH-11290568

• Finding genes behind male infertility

  This project uses long-read DNA sequencing to find genes and mutations that may cause infertility in men.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11223320

• How health insurance affects infertility treatment and birth outcomes

  This study looks at how different health insurance plans affect choices people make about in vitro fertilization (IVF) and embryo transfers, with the goal of finding the best coverage options to help those struggling with infertility have healthy pregnancies.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11196071

• Genetic causes of male infertility and azoospermia

  This project aims to find gene changes that cause nonobstructive azoospermia in men to improve diagnosis and guide future treatments.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-11194422

• A new non-invasive test for diagnosing endometriosis in women facing infertility

  This study is working on a simple and non-invasive test using menstrual fluid to help diagnose endometriosis earlier, which could make it easier for women to get the care they need and improve their chances of having children.

  NIH research Nextgenjane, INC. · Oakland, UNITED STATES · NIH-11185524

• Infertility and long-term health in Hispanic women of Mexican heritage

  This project looks at whether having trouble getting pregnant is linked to later risks of cancer, diabetes, and heart-related disease in Hispanic women with Mexican roots.

  NIH research University of Arizona · Tucson, United States · NIH-11175413

• Blocking TNFR2 to prevent chlamydia-related infertility

  This project tests whether blocking the TNFR2 protein can stop damaging inflammation from chlamydia infections and help protect people from pelvic inflammatory disease and infertility.

  NIH research Yale University · New Haven, United States · NIH-11159793

• Understanding the genetic causes of infertility in humans

  This study is looking at how our genes might play a role in infertility, helping couples who are trying to have a baby by finding out more about the genetic factors that could be affecting them.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11124180

• Understanding the genetic causes of rare infertility disorders

  This study is looking into the genetic causes of certain rare infertility issues to help improve diagnosis and treatment options for people facing these challenges.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11124175

• Exploring the link between genetic mutations and male infertility

  This study is looking at how higher rates of genetic changes in men might be linked to infertility and other health problems, and it involves men with varying fertility levels who will provide samples to help us understand these connections better.

  NIH research University of Utah · Salt Lake City, United States · NIH-11120851

• Understanding how genetic variations affect sperm development and male infertility

  This study is looking at how certain genetic differences might affect sperm development and quality in men who are having trouble with infertility, with the hope of finding helpful markers for diagnosis and treatment.

  NIH research Cornell University · Ithaca, United States · NIH-11083780

• Understanding how genes affect sperm development and infertility

  This study is looking into how genes and molecules help create healthy sperm and what can go wrong to cause infertility, with the hope that the findings will lead to better treatments for people trying to conceive.

  NIH research Cornell University · Ithaca, United States · NIH-11083777

• Exploring how body clocks affect infertility caused by Chlamydia

  This study is looking at how our body clocks might affect fertility issues caused by Chlamydia infections, using mice to see if the timing of the infection makes a difference in how severe the problem is, which could help us understand more about how to support those facing infertility.

  NIH research Morehouse School of Medicine · Atlanta, United States · NIH-11074601

• Exploring the connection between cancer and infertility in women

  This study is looking at how a specific protein might connect cancer and infertility in women, aiming to understand why women who have trouble getting pregnant may also face a higher risk of cancer, using a special yeast model to explore these links.

  NIH research University of Southern Mississippi · Hattiesburg, United States · NIH-11037520

• New test to help men with severe infertility and improve their health outcomes

  This study is looking to create a new test that helps men with severe infertility, especially those with a condition called Non-Obstructive Azoospermia, by understanding the genetic factors that might affect their health and fertility, so they can get better support and treatment options.

  NIH research Inherent Biosciences, INC. · Salt Lake City, UNITED STATES · NIH-11026097

• Understanding the genetics behind male infertility

  This study is looking at the genes that might cause male infertility, especially a condition called nonobstructive azoospermia, which affects about 1 in 100 men, to help create better tests and treatments for couples dealing with infertility.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-10992989

• Blocking a specific receptor to prevent infertility caused by chlamydia infections

  This study is looking at whether blocking a specific receptor can help prevent infertility caused by chlamydia infections, using mice to see how this might work and potentially help people dealing with infertility from STIs.

  NIH research Yale University · New Haven, United States · NIH-10986536

• Identifying new genes linked to male infertility

  This study is looking at the DNA of men who have trouble fathering children to find out if there are specific genes or changes in their genes that might be causing infertility, and it hopes to help improve how we diagnose these issues in the future.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10983775

• A new 3D printed device for delivering progesterone to help with infertility

  This study is testing a new 3D printed ring that releases progesterone over 28 days to help women going through fertility treatments like IVF, making it easier and more convenient for them to get the hormones they need.

  NIH research Anelleo, INC. · Chapel Hill, United States · NIH-10932305

• Understanding infertility and its effects in low-resource countries

  This study is looking at how infertility affects people in low-resource countries, especially in sub-Saharan Africa, by understanding the emotional struggles and social stigma they face, so we can find better ways to support those dealing with infertility.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10910044

• Infertility's impact on long-term health in Hispanic women with Mexican heritage

  This study looks at how infertility might affect the long-term health of Hispanic women with Mexican heritage, especially regarding risks for conditions like cancer and heart disease, to better understand their unique health challenges.

  NIH research University of Arizona · Tucson, United States · NIH-10869530

• Annual conference on reproductive biology and infertility

  This study is all about hosting a friendly two-day conference where experts and trainees come together to learn and talk about reproductive health and infertility, helping everyone understand the science behind it better and supporting the next generation of professionals in this important field.

  NIH research Cornell University · Ithaca, United States · NIH-10837071

• How air pollution and temperature affect men's fertility and infertility treatments

  This study looks at how air pollution and temperature changes might affect men's sperm health and fertility, helping us understand more about male infertility and how it can impact couples trying to conceive.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-10830942

• How heat affects fertility through gene regulation in sperm and eggs

  This study looks at how heat can affect fertility by exploring how certain tiny molecules in sperm and eggs respond to heat stress, which could help us understand why some people might face infertility or birth defects due to environmental factors.

  NIH research University of Oregon · Eugene, United States · NIH-10748387

• How exposure to certain chemicals affects male fertility

  This study is looking at how certain chemicals in our environment might affect fertility later in life and even impact future generations, especially by studying how these chemicals change genes and cell function in the testicles, with the goal of finding ways to prevent and treat infertility caused by these factors.

  NIH research University of Florida · Gainesville, United States · NIH-10732255

• Investigating the link between uranium exposure and infertility in a community cohort.

  This study is looking at how being around uranium might affect the ability to have children for people who lived in the Fernald area, and it’s for anyone from that community who wants to help us understand the possible impacts on reproductive health.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-10666344

Related topics

Quick answers

How many Infertility clinical trials are recruiting right now?

94, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (20 trials), China (13 trials), Spain (9 trials), France (7 trials), Denmark (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 3: 4, Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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