Ovarian PRP injections to try to improve embryo quality

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

After an initial IVF cycle, participants receive an autologous PRP injection into both ovaries under transvaginal ultrasound guidance and IV sedation roughly 1–2 weeks after the next menstrual cycle begins. A second IVF cycle uses the same stimulation protocol, with a second ovarian PRP injection on stimulation days 2–5, followed by oocyte retrieval and fertilization under the same conditions as the first cycle. Up to 15 embryos per participant are cultured in a time-lapse AI incubator to track morphokinetics, and AI software scores embryo viability and implantation potential. The trial enrolls people without contraindications to IVF or PRP who are willing to undergo two IVF cycles and meet ovarian reserve/AMH requirements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* No none contraindications to IVF or PRP treatment
* Adequate ovarian reserves and AMH level
* Willingness to undergo two IVF cycles and oPRP treatment

Exclusion Criteria:

* Anovulation due to menopause or perimenopause
* Any health conditions that are contraindicated for IVF or oPRP treatment

Where it's running

• Generation Next Fertility
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jesse Hade, MD — Generation Next Fertility
• Study coordinator: Alicia L Broussard, PhD
• Email: a.broussard@generationnextfertility.com
• Phone: 3174456958

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using antioxidant-rich media to improve embryo quality in IVF

  This study is testing if using a special culture solution with antioxidants can help improve the quality of embryos for people undergoing IVF.

  Recruiting ART Fertility Clinics LLC · Abu Dhabi, Abu Dhabi Emirate · NCT06261671

• AI-assisted embryo selection on day 5 in IVF for infertility

  This trial tests whether an AI-based embryo selection tool can help pick the best embryo for transfer on day 5 in IVF/ICSI to improve pregnancy chances for people with infertility.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07844083

• Preserving sperm quality with aging through cryopreservation

  This study tests whether freezing and thawing sperm can help keep younger-like DNA and molecular traits in men as they age.

  Recruiting IVI Murcia · Murcia, Murcia · NCT07814235

• Unstimulated Egg Retrieval with CAPA-IVM and Euploid Embryo Transfer

  This study tests whether eggs can be collected without ovarian stimulation, matured in the lab, and used to create a single euploid embryo for transfer in infertility patients.

  Recruiting CARE Fertility Texas · Bedford, Texas · NCT07801105

• Ultra-Long GnRH-a Pretreatment Before Frozen Embryo Transfer for Deep Infiltrating Endometriosis

  In people under 40 with deep infiltrating endometriosis and infertility, the study tests whether two injections of a GnRH agonist before hormone support improve pregnancy outcomes in their first frozen-thawed embryo transfer.

  Recruiting Phase 4 Nanjing University · Nanjing, Jiangsu · NCT07696351

• Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy

  This study tests whether patterns of uterine contractions during hormone-prepared frozen embryo transfer affect pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City · NCT07675213

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.