Investigating the effects of immune cell treatment on endometrial health for infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore how the administration of autologous peripheral blood mononuclear cells (PBMC) modulated with interferon tau (IFNt) affects the composition of the endometrium during the critical window of implantation in women experiencing unexplained infertility. Female participants will undergo two endometrial biopsies: one prior to the treatment and another after the intrauterine administration of the modulated PBMC. The study will analyze changes in endometrial cell populations using immunohistochemistry techniques to assess the potential impact of this treatment on fertility outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participating in Assisted Reproduction Treatment
* Having primary infertility
* Having regular menstrual cycles
* Having signed informed consent

Exclusion Criteria:

* Uterine pathologies
* Endometrial bacterial infections
* Active endometrial inflammation
* Polycystic ovary syndrome
* Presence of auto antibodies such as anti-TPO (thyroid peroxidase), anti-TG (thyroglobulin), ACA (anticentromere antibodies), APA (antiphospholipid antibodies), ANA (antinuclear antibodies), and anti-dsDNA
* Presence of mutations involving the coagulation system such as deficiency of factor XII, Pro C, Pro S
* Oncological condition
* Positive HIV (human immunodeficiency virus), HCV (hepatitis C virus) or HBV (hepatitis B virus) tests

Where it's running

• Nadezhda Women's Health Hospital
  Sofia, Sofia, Bulgaria Recruiting

Study contacts

• Study coordinator: Dimitar Parvanov, PhD
• Email: dimparvanov@abv.bg
• Phone: 885944618

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.