Comparing two methods for processing semen quality in infertility treatment
Effect of Sperm Preparation by a Microfluidic Chip Method Versus a Density Gradient Centrifugation Method on Semen Parameters
This study is testing a new way to process semen to see if it can better preserve sperm quality for men undergoing infertility treatment compared to the traditional method.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Sex | Male |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong, Hong Kong) |
| Trial ID | NCT05978947 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a new microfluidic chip technology against the traditional density gradient centrifugation method for processing semen in men attending a fertility clinic. The research aims to determine which method better preserves sperm quality, specifically focusing on DNA fragmentation, sperm count, and motility. Participants will have their semen samples randomly assigned to one of the two processing methods, and various tests will be conducted to assess the outcomes. The goal is to improve IVF success rates by enhancing the quality of sperm used in fertilization.
Who should consider this trial
Good fit: Ideal candidates for this study are men with a sperm concentration of at least 5 million motile sperm per ml and a total semen volume of not less than 1.5 ml.
Not a fit: Patients with a sperm concentration of less than 5 million motile sperm per ml or those unable to provide an ejaculated semen sample may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved sperm quality and higher IVF success rates for couples facing infertility.
How similar studies have performed: While the use of microfluidic technology in semen processing is a relatively novel approach, similar studies have shown promising results in improving sperm quality.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml. Exclusion Criteria: * Sperm concentration of the raw semen of less than 5 million motile sperm per ml * Men unable to provide an ejaculated semen sample
Where this trial is running
Hong Kong, Hong Kong
- Department of Obstetrics and Gynaecology — Hong Kong, Hong Kong, China (Recruiting)
Study contacts
- Study coordinator: Yu Wing Tong, Mbbs
- Email: ptong@connect.hku.hk
- Phone: 92707722
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.