Comparing two methods for processing semen quality in infertility treatment
Official title: Effect of Sperm Preparation by a Microfluidic Chip Method Versus a Density Gradient Centrifugation Method on Semen Parameters
Run by The University of Hong Kong · NCT05978947 · Data updated 2026-11-12
This study is testing a new way to process semen to see if it can better preserve sperm quality for men undergoing infertility treatment compared to the traditional method.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | Men only |
| Enrollment | 80 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong, Hong Kong) |
| Status | Recruiting |
| Started | July 1, 2023 |
| Main results expected | March 31, 2025 |
| Study ends | March 31, 2025 |
| Registry record updated | December 5, 2024 |
| Trial ID | NCT05978947 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are men with a sperm concentration of at least 5 million motile sperm per ml and a total semen volume of not less than 1.5 ml.
✕Probably not a fit
Patients with a sperm concentration of less than 5 million motile sperm per ml or those unable to provide an ejaculated semen sample may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of a new microfluidic chip technology against the traditional density gradient centrifugation method for processing semen in men attending a fertility clinic. The research aims to determine which method better preserves sperm quality, specifically focusing on DNA fragmentation, sperm count, and motility. Participants will have their semen samples randomly assigned to one of the two processing methods, and various tests will be conducted to assess the outcomes. The goal is to improve IVF success rates by enhancing the quality of sperm used in fertilization.
Why it matters
Potential benefit: If successful, this study could lead to improved sperm quality and higher IVF success rates for couples facing infertility.
How similar studies have gone: While the use of microfluidic technology in semen processing is a relatively novel approach, similar studies have shown promising results in improving sperm quality.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml. Exclusion Criteria: * Sperm concentration of the raw semen of less than 5 million motile sperm per ml * Men unable to provide an ejaculated semen sample
Where it's running
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Department of Obstetrics and Gynaecology
Hong Kong, Hong Kong, China Recruiting
Study contacts
- Study coordinator: Yu Wing Tong, Mbbs
- Email: ptong@connect.hku.hk
- Phone: 92707722
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.