Examining discarded materials from IVF cycles to understand treatment outcomes
What To-be-discard Biomaterials From ART Cycles Can Tell us About the Treatment Cycle Outcome?
Chinese University of Hong Kong · NCT06021340
This study is trying to see if analyzing leftover materials from IVF cycles can help predict which treatments will be successful and improve the chances of pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong (other) |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06021340 on ClinicalTrials.gov |
What this trial studies
This observational study collects and analyzes various discarded materials from in vitro fertilization (IVF) treatment cycles, such as immature oocytes and abnormal embryos, to identify potential indicators of successful outcomes or cycle failures. The study employs next-generation sequencing for DNA and RNA analysis, along with transcriptome profiling and protein analysis, to explore the underlying reasons for IVF success or failure. The goal is to develop a non-invasive testing method for assessing embryo quality and improving implantation potential, ultimately enhancing clinical outcomes in IVF treatments.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing assisted reproductive technology (ART) treatment at the Chinese University of Hong Kong.
Not a fit: Patients using donor gametes for IVF treatment or those who do not provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved methods for assessing embryo quality, increasing the chances of successful IVF outcomes for patients.
How similar studies have performed: While the approach of analyzing discarded IVF materials is innovative, similar studies have shown promise in understanding embryo quality and improving IVF outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients attending the Assisted Reproductive Technology (ART) Unit of the Chinese University of Hong Kong for ART treatment. * Participant able to give voluntary, written, informed consent to participate in the study. Exclusion Criteria: * Patient using donor gamete in IVF treatment * Patient refuses to join and failed to giving consent for any reasons
Where this trial is running
Hong Kong
- The Chinese University of Hong Kong and Prince of Wales Hospital — Hong Kong, Hong Kong (RECRUITING)
Study contacts
- Principal investigator: Yiu Leung D Chan, DPhil — CUHK
- Study coordinator: Yiu Leung D Chan, DPhil
- Email: drdcyl16@cuhk.edu.hk
- Phone: (852) 3505 3199
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: IVF, Infertility